Encephalopathy due to lead (Q86148): Difference between revisions
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A encefalopatia por chumbo é muito mais rara em adultos do que em crianças, porque o cérebro adulto maduro é tem maior capacidade de sequestrar o chumbo de seu local de ação mitocondrial dentro dos neurônios cerebrais e cerebelares. O chumbo atua como uma toxina celular inibindo a cadeia respiratória mitocondrial. Acredita-se que as lesões no sistema nervoso central sejam o resultado de uma lesão vascular. | |||
| description / en | description / en | ||
Lead encephalopathy is much rarer in adults than in children because the mature adult brain is more able to sequester lead away from its mitochondrial site of action within cerebral and cerebellar neurons. Lead acts as a cellular toxin by inhibiting mitochondrial respiration. Lesions in the central nervous system are thought to be the result of vascular injury. | |||
Revision as of 11:30, 15 August 2026
Lead encephalopathy is much rarer in adults than in children because the mature adult brain is more able to sequester lead away from its mitochondrial site of action within cerebral and cerebellar neurons. Lead acts as a cellular toxin by inhibiting mitochondrial respiration. Lesions in the central nervous system are thought to be the result of vascular injury.
| Language | Label | Description | Also known as |
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| default for all languages | ID_398750634 |
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| English | Encephalopathy due to lead |
Lead encephalopathy is much rarer in adults than in children because the mature adult brain is more able to sequester lead away from its mitochondrial site of action within cerebral and cerebellar neurons. Lead acts as a cellular toxin by inhibiting mitochondrial respiration. Lesions in the central nervous system are thought to be the result of vascular injury. |
