Severe haemophilia A (Q85311): Difference between revisions
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Hemofilia A grave é uma forma de hemofilia A (veja este termo) caracterizada por uma deficiência importante de fator VIII, levando a hemorragias espontâneas frequentes e a sangramento anormal como resultado de ferimentos menores, ou subsequente a cirurgias ou extrações dentárias. Hemofilia A grave responde por cerca de 40% de todos os casos de hemofilia A. A atividade biológica do fator VIII é inferior a 1%. A tranmissão é recessiva ligada ao X, e o transtorno é causado por mutações no gene F8 (Xq28), que codifica o fator VIII da coagulação. | |||
| description / en | description / en | ||
Severe haemophilia A is a form of haemophilia A (see this term) characterised by a large deficiency of factor VIII leading to frequent spontaneous haemorrhage and abnormal bleeding as a result of minor injuries, or following surgery or tooth extraction. Severe haemophilia A accounts for around 40% of all cases of haemophilia A. The biological activity of factor VIII is below 1%. Transmission is X-linked recessive and the disorder is caused by mutations in the F8 gene (Xq28) encoding coagulation factor VIII. | |||
Revision as of 10:40, 15 August 2026
Severe haemophilia A is a form of haemophilia A (see this term) characterised by a large deficiency of factor VIII leading to frequent spontaneous haemorrhage and abnormal bleeding as a result of minor injuries, or following surgery or tooth extraction. Severe haemophilia A accounts for around 40% of all cases of haemophilia A. The biological activity of factor VIII is below 1%. Transmission is X-linked recessive and the disorder is caused by mutations in the F8 gene (Xq28) encoding coagulation factor VIII.
| Language | Label | Description | Also known as |
|---|---|---|---|
| default for all languages | ID_96616786 |
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| English | Severe haemophilia A |
Severe haemophilia A is a form of haemophilia A (see this term) characterised by a large deficiency of factor VIII leading to frequent spontaneous haemorrhage and abnormal bleeding as a result of minor injuries, or following surgery or tooth extraction. Severe haemophilia A accounts for around 40% of all cases of haemophilia A. The biological activity of factor VIII is below 1%. Transmission is X-linked recessive and the disorder is caused by mutations in the F8 gene (Xq28) encoding coagulation factor VIII. |
