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In about 5% of patients with coeliac disease, symptoms and villous atrophy persist or newly develop despite scrupulous adherence to a gluten-free diet. This syndrome is known as refractory sprue and required extensive investigation.
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    Refractory coeliac sprue
    In about 5% of patients with coeliac disease, symptoms and villous atrophy persist or newly develop despite scrupulous adherence to a gluten-free diet. This syndrome is known as refractory sprue and required extensive investigation.

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