Fetal Valproate Spectrum Disorder (Q46693): Difference between revisions
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Transtorno do espectro do valproato fetal e a síndrome do valproato fetal (FVS) descrevem a gama de sinais e sintomas que ocorrem como consequência da exposição ao valproato de sódio ou ácido valpróico no útero. Uma ampla variedade de anomalias físicas ocorre com frequência aumentada, incluindo espinha bífida, anormalidades maiores e menores nos membros, fissura oral, defeitos cardíacos, hipospádia e frouxidão articular. Um padrão característico de dismorfismo facial está frequentemente presente, especialmente notável na primeira infância. Problemas de neurodesenvolvimento, incluindo QI reduzido, linguagem e desenvolvimento motor mais pobres, taxas aumentadas de transtorno do espectro autista e transtorno de déficit de atenção e hiperatividade são observados em até 40% dos expostos. Problemas de visão como miopia e astigmatismo também são comuns. Os riscos dependem da dose e o impacto no cérebro pode ser observado em doses menores do que as necessárias para as alterações do desenvolvimento físico. | |||
| description / en | description / en | ||
Fetal valproate spectrum disorder (FVSD) and Fetal valproate syndrome (FVS) describe the range of signs and symptoms which occur as a consequence of exposure to sodium valproate or valproic acid in the womb. A wide range of physical anomalies occur at increased frequency, including spina bifida, major and minor limb abnormalities, oral clefting, cardiac defects, hypospadias, and joint laxity. A characteristic pattern of facial dysmorphism is frequently present, especially notable in early childhood. Neurodevelopmental problems including reduced IQ, poorer language and motor development, increased rates of autistic spectrum disorder and attention deficit hyperactivity disorder are observed in up to 40% of those exposed. Vision problems such as myopia and astigmatism are also common. Risks are dose dependent and the impact on the brain may be seen at lower doses than those required for physical development alterations. | |||
Revision as of 15:27, 13 August 2026
Fetal valproate spectrum disorder (FVSD) and Fetal valproate syndrome (FVS) describe the range of signs and symptoms which occur as a consequence of exposure to sodium valproate or valproic acid in the womb. A wide range of physical anomalies occur at increased frequency, including spina bifida, major and minor limb abnormalities, oral clefting, cardiac defects, hypospadias, and joint laxity. A characteristic pattern of facial dysmorphism is frequently present, especially notable in early childhood. Neurodevelopmental problems including reduced IQ, poorer language and motor development, increased rates of autistic spectrum disorder and attention deficit hyperactivity disorder are observed in up to 40% of those exposed. Vision problems such as myopia and astigmatism are also common. Risks are dose dependent and the impact on the brain may be seen at lower doses than those required for physical development alterations.
| Language | Label | Description | Also known as |
|---|---|---|---|
| default for all languages | LD2F.03 |
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| English | Fetal Valproate Spectrum Disorder |
Fetal valproate spectrum disorder (FVSD) and Fetal valproate syndrome (FVS) describe the range of signs and symptoms which occur as a consequence of exposure to sodium valproate or valproic acid in the womb. A wide range of physical anomalies occur at increased frequency, including spina bifida, major and minor limb abnormalities, oral clefting, cardiac defects, hypospadias, and joint laxity. A characteristic pattern of facial dysmorphism is frequently present, especially notable in early childhood. Neurodevelopmental problems including reduced IQ, poorer language and motor development, increased rates of autistic spectrum disorder and attention deficit hyperactivity disorder are observed in up to 40% of those exposed. Vision problems such as myopia and astigmatism are also common. Risks are dose dependent and the impact on the brain may be seen at lower doses than those required for physical development alterations. |
