Toxic epidermal necrolysis (Q43950): Difference between revisions
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Necrólise epidérmica tóxica (NET) é uma doença cutânea aguda com risco de vida, com risco geral de mortalidade comumente citado entre 25 e 30%, embora o risco de desfecho fatal seja de cerca de 90% nos pacientes mais gravemente afetados (escore SCORTEN > 5). Caracteriza-se pelo rápido início de extenso eritema, necrose e descolamento bolhoso da epiderme (> 30% da área de superfície corporal). Comumente, as mucosas também estão envolvidas. A morte pode resultar de uma combinação de sepse, depleção de fluidos e falência de múltiplos órgãos. Em dois terços dos casos, a NET é desencadeada por uma alergia a medicamentos claramente identificável. | |||
| description / en | description / en | ||
Toxic epidermal necrolysis (TEN) is an acute life-threatening skin disease with commonly quoted overall risk of mortality of between 25 and 30%, though the risk of fatal outcome is around 90% in the most severely affected patients (SCORTEN score >5). It is characterised by the rapid onset of extensive erythema, necrosis, and bullous detachment of the epidermis (> 30% body surface area). Commonly, the mucous membranes are also involved. Death may result from a combination of sepsis, fluid depletion and multi-organ failure. In two thirds of cases, TEN is triggered by a clearly identifiable drug allergy. | |||
Revision as of 11:11, 13 August 2026
Toxic epidermal necrolysis (TEN) is an acute life-threatening skin disease with commonly quoted overall risk of mortality of between 25 and 30%, though the risk of fatal outcome is around 90% in the most severely affected patients (SCORTEN score >5). It is characterised by the rapid onset of extensive erythema, necrosis, and bullous detachment of the epidermis (> 30% body surface area). Commonly, the mucous membranes are also involved. Death may result from a combination of sepsis, fluid depletion and multi-organ failure. In two thirds of cases, TEN is triggered by a clearly identifiable drug allergy.
| Language | Label | Description | Also known as |
|---|---|---|---|
| default for all languages | EB13.1 |
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| English | Toxic epidermal necrolysis |
Toxic epidermal necrolysis (TEN) is an acute life-threatening skin disease with commonly quoted overall risk of mortality of between 25 and 30%, though the risk of fatal outcome is around 90% in the most severely affected patients (SCORTEN score >5). It is characterised by the rapid onset of extensive erythema, necrosis, and bullous detachment of the epidermis (> 30% body surface area). Commonly, the mucous membranes are also involved. Death may result from a combination of sepsis, fluid depletion and multi-organ failure. In two thirds of cases, TEN is triggered by a clearly identifiable drug allergy. |
