Mikulicz disease (Q43136): Difference between revisions
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Doença de Mikulicz é um transtorno relatado pela primeira vez por Johann von Mikulicz em 1892 e caracterizado por edema simétrico das glândulas lacrimais, submandibulares e parótidas, com infiltração maciça dessas glândulas por células mononucleares. Autoanticorpos séricos, como anti-Ro/SS-A, são geralmente negativos e a concentração sérica de IgG4 pode estar aumentada. Ao contrário da doença de Sjögren, a doença IgG4-Mikulicz é caracterizada pela formação de folículos linfoides, mas apresenta níveis mais baixos de infiltração linfocítica nos ductos salivares, de modo que sua estrutura permanece intacta. | |||
| description / en | description / en | ||
Mikulicz disease is a disorder first reported by Johann von Mikulicz in 1892 and characterised by symmetrical swelling of the lachrymal, submandibular, and parotid glands, with massive infiltration of these glands by mononuclear cells. Serum autoantibodies, such as anti-Ro/SS-A, are usually negative and serum IgG4 concentration may be increased. Unlike Sjögren disease, IgG4-Mikulicz disease is characterised by the formation of lymphoid follicles, but shows lower levels of lymphocytic infiltration into salivary ducts, such that their structure remains intact. | |||
Revision as of 09:59, 13 August 2026
Mikulicz disease is a disorder first reported by Johann von Mikulicz in 1892 and characterised by symmetrical swelling of the lachrymal, submandibular, and parotid glands, with massive infiltration of these glands by mononuclear cells. Serum autoantibodies, such as anti-Ro/SS-A, are usually negative and serum IgG4 concentration may be increased. Unlike Sjögren disease, IgG4-Mikulicz disease is characterised by the formation of lymphoid follicles, but shows lower levels of lymphocytic infiltration into salivary ducts, such that their structure remains intact.
| Language | Label | Description | Also known as |
|---|---|---|---|
| default for all languages | 4A43.1 |
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| English | Mikulicz disease |
Mikulicz disease is a disorder first reported by Johann von Mikulicz in 1892 and characterised by symmetrical swelling of the lachrymal, submandibular, and parotid glands, with massive infiltration of these glands by mononuclear cells. Serum autoantibodies, such as anti-Ro/SS-A, are usually negative and serum IgG4 concentration may be increased. Unlike Sjögren disease, IgG4-Mikulicz disease is characterised by the formation of lymphoid follicles, but shows lower levels of lymphocytic infiltration into salivary ducts, such that their structure remains intact. |
