White matter disorder due to vitamin B12 deficiency (Q41168): Difference between revisions
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Características neurológicas ocorrem em 40% dos pacientes com deficiência de vitamina B12. Degeneração combinada subaguda é uma complicação neurológica reversível potencial de deficiência de vitamina B12. Sintomas desenvolvem de forma insidiosa e as manifestações neuropáticas incluem parestesia distal, dormência, ataxia de marcha e diminuição da propriocepção dos membros inferiores, enquanto componente mielopático leva à prejuízo motor variável devido à disfunção do trato piramidal. Incontinência fecal e urinária com impotência e hipotensão postural podem ocorrer como parte da mielopatia. Manifestações centrais incluem confusão, depressão, alucinação progressiva e lentificação mental. Pode ocorrer e neuropatia óptica. | |||
| description / en | description / en | ||
Neurological features occur in 40% of patients with B12 deficiency. Subacute combined degeneration is a potentially reversible neurological complication of a vitamin B12 deficiency. Symptoms develop insidiously and neuropathic manifestations include progressive paraesthesia distally, numbness, gait ataxia and diminished proprioception in the lower limbs, while the myelopathic component leads to variable motor impairment due to pyramidal tract dysfunction. Incontinence of bowel and bladder with impotence and postural hypotension occur as part of the myelopathy. Central manifestations include confusion, depression, progressive hallucination and mental slowing. There may also be optic neuropathy present. | |||
Revision as of 07:13, 13 August 2026
Neurological features occur in 40% of patients with B12 deficiency. Subacute combined degeneration is a potentially reversible neurological complication of a vitamin B12 deficiency. Symptoms develop insidiously and neuropathic manifestations include progressive paraesthesia distally, numbness, gait ataxia and diminished proprioception in the lower limbs, while the myelopathic component leads to variable motor impairment due to pyramidal tract dysfunction. Incontinence of bowel and bladder with impotence and postural hypotension occur as part of the myelopathy. Central manifestations include confusion, depression, progressive hallucination and mental slowing. There may also be optic neuropathy present.
| Language | Label | Description | Also known as |
|---|---|---|---|
| default for all languages | 8A45.30 |
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| English | White matter disorder due to vitamin B12 deficiency |
Neurological features occur in 40% of patients with B12 deficiency. Subacute combined degeneration is a potentially reversible neurological complication of a vitamin B12 deficiency. Symptoms develop insidiously and neuropathic manifestations include progressive paraesthesia distally, numbness, gait ataxia and diminished proprioception in the lower limbs, while the myelopathic component leads to variable motor impairment due to pyramidal tract dysfunction. Incontinence of bowel and bladder with impotence and postural hypotension occur as part of the myelopathy. Central manifestations include confusion, depression, progressive hallucination and mental slowing. There may also be optic neuropathy present. |
