AL amyloidosis (Q40143): Difference between revisions
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Amiloidose AL (amiloidose de cadeia leve) é devida à deposição de cadeias leves de imunoglobulina nos glomérulos, onde são vistas como fibrilas de ligação ao vermelho do Congo e imunocoradas especificamente para cadeias leves kappa ou lambda. À microscopia de luz, há material hialino amorfo no mesângio e nas paredes capilares. Um plasmócito produtor de cadeia leve ou uma displasia de células B é o responsável. Outros órgãos também estão envolvidos nessa doença sistêmica. | |||
| description / en | description / en | ||
AL (Amyloid Light-Chain) Amyloidosis is due to the deposition of immunoglobulin light chains in glomeruli where they are seen as Congo red binding fibrils and immuno-stain specifically for kappa or lambda light chains. By light microscopy there is amorphous hyaline material in the mesangium and capillary walls. A light chain producing plasma cell or B-cell dysplasia is responsible. Other organs are also involved in this systemic disease. | |||
Revision as of 05:50, 13 August 2026
AL (Amyloid Light-Chain) Amyloidosis is due to the deposition of immunoglobulin light chains in glomeruli where they are seen as Congo red binding fibrils and immuno-stain specifically for kappa or lambda light chains. By light microscopy there is amorphous hyaline material in the mesangium and capillary walls. A light chain producing plasma cell or B-cell dysplasia is responsible. Other organs are also involved in this systemic disease.
| Language | Label | Description | Also known as |
|---|---|---|---|
| default for all languages | 5D00.0 |
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| English | AL amyloidosis |
AL (Amyloid Light-Chain) Amyloidosis is due to the deposition of immunoglobulin light chains in glomeruli where they are seen as Congo red binding fibrils and immuno-stain specifically for kappa or lambda light chains. By light microscopy there is amorphous hyaline material in the mesangium and capillary walls. A light chain producing plasma cell or B-cell dysplasia is responsible. Other organs are also involved in this systemic disease. |
