Wernicke-Korsakoff Syndrome (Q39917): Difference between revisions
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Síndrome de deficiência de tiamina caracteriza-se por lesões hiperêmicas simétricas do tronco encefálico, hipotálamo, tálamo e corpos mamilares com proliferação glial, dilatação capilar e hemorragia perivascular. A síndrome se manifesta por um estado confusional, desorientação, oftalmoplegia, nistagmo, diplopia e ataxia (encefalopatia de Wernicke), com grave perda de memória para eventos recentes e confabulação ( invenção de relatos de eventos para cobrir a perda de memória - Korsakov psicose) ocorrendo após a recuperação. Foi encontrada ligação defeituosa do difosfato de tiamina pela transcetolase. Parece que o transtorno é de herança autossômica recessiva, mas é expresso como doença clínica apenas no caso de deficiência de tiamina. | |||
| description / en | description / en | ||
A thiamine-deficiency syndrome characterised by symmetric hyperaemic lesions of the brainstem, hypothalamus, thalamus, and mammillary bodies with glial proliferation, capillary dilatation, and perivascular haemorrhage. The syndrome is manifested by a confusional state, disorientation, ophthalmoplegia, nystagmus, diplopia, and ataxia (Wernicke encephalopathy), with severe loss of memory for recent events and confabulation (the invention of accounts of events to cover the loss of memory) (Korsakov psychosis) occurring following recovery. Defective binding of thiamine diphosphate by transketolase has been found. It appears that the disorder is of autosomal recessive inheritance but is expressed as clinical disease only in the event of thiamine deficiency. | |||
Revision as of 05:31, 13 August 2026
A thiamine-deficiency syndrome characterised by symmetric hyperaemic lesions of the brainstem, hypothalamus, thalamus, and mammillary bodies with glial proliferation, capillary dilatation, and perivascular haemorrhage. The syndrome is manifested by a confusional state, disorientation, ophthalmoplegia, nystagmus, diplopia, and ataxia (Wernicke encephalopathy), with severe loss of memory for recent events and confabulation (the invention of accounts of events to cover the loss of memory) (Korsakov psychosis) occurring following recovery. Defective binding of thiamine diphosphate by transketolase has been found. It appears that the disorder is of autosomal recessive inheritance but is expressed as clinical disease only in the event of thiamine deficiency.
| Language | Label | Description | Also known as |
|---|---|---|---|
| default for all languages | 5B5A.1 |
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| English | Wernicke-Korsakoff Syndrome |
A thiamine-deficiency syndrome characterised by symmetric hyperaemic lesions of the brainstem, hypothalamus, thalamus, and mammillary bodies with glial proliferation, capillary dilatation, and perivascular haemorrhage. The syndrome is manifested by a confusional state, disorientation, ophthalmoplegia, nystagmus, diplopia, and ataxia (Wernicke encephalopathy), with severe loss of memory for recent events and confabulation (the invention of accounts of events to cover the loss of memory) (Korsakov psychosis) occurring following recovery. Defective binding of thiamine diphosphate by transketolase has been found. It appears that the disorder is of autosomal recessive inheritance but is expressed as clinical disease only in the event of thiamine deficiency. |
