Malignant neoplasms of adrenal gland (Q39015): Difference between revisions
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Os tumores que se originam do córtex adrenal incluem adenomas e carcinomas. Estas são neoplasias raras, mas podem causar uma série de sintomas hormonais, incluindo hiperaldosteronismo, síndrome de Cushing e virilização. Uma pequena fração dos tumores adrenocorticais está associada a uma síndrome tumoral hereditária, incluindo a síndrome de Li-Fraumeni e o complexo de Carney._x000D_ Feocromocitomas benignos e malignos surgem na medula adrenal e são derivados de células cromafins com origem na crista neural. Os feocromocitomas podem ocorrer no contexto de várias condições hereditárias, incluindo neoplasia endócrina múltipla dos tipos 2a e 2b, doença de von Hippel Lindau e neurofibromatose._x000D_ Os paragangliomas extra-adrenais se originam de células cromafins nos paragânglios simpatoadrenais e parassimpáticos. Eles ocorrem em muitas partes do corpo e podem representar um desafio significativo para cirurgiões e oncologistas. Alguns funcionam como quimiorreceptores, outros são endocrinologicamente ativos. Os paragangliomas familiares estão associados a mutações dos genes do complexo II mitocondrial. | |||
| description / en | description / en | ||
Tumours arising from the adrenal cortex include adenomas and carcinomas. These are rare neoplasms but may cause a variety of hormonal symptoms, including hyperaldosteronism, Cushing syndrome, and virilisation. A small fraction of adrenocortical tumours are associated with an inherited tumour syndrome, including Li-Fraumeni syndrome and Carney complex. Benign and malignant phaeochromocytomas arise in the adrenal medulla and are derived from chromaffin cells of neural crest origin. Phaeochromocytomas may occur in the setting of several hereditary conditions, including multiple endocrine neoplasia types 2a and 2b, von Hippel Lindau disease and neurofibromatosis. Extra adrenal paragangliomas arise from chromaffin cells in sympathoadrenal and parasympathetic paraganglia. They occur in many parts of the body and can pose a significant challenge to surgeons and oncologists. Some function as chemoreceptors, others are endocrinologically active. Familial paragangliomas are associated with mutations of the mitochondrial complex II genes. | |||
Revision as of 04:19, 13 August 2026
Tumours arising from the adrenal cortex include adenomas and carcinomas. These are rare neoplasms but may cause a variety of hormonal symptoms, including hyperaldosteronism, Cushing syndrome, and virilisation. A small fraction of adrenocortical tumours are associated with an inherited tumour syndrome, including Li-Fraumeni syndrome and Carney complex. Benign and malignant phaeochromocytomas arise in the adrenal medulla and are derived from chromaffin cells of neural crest origin. Phaeochromocytomas may occur in the setting of several hereditary conditions, including multiple endocrine neoplasia types 2a and 2b, von Hippel Lindau disease and neurofibromatosis. Extra adrenal paragangliomas arise from chromaffin cells in sympathoadrenal and parasympathetic paraganglia. They occur in many parts of the body and can pose a significant challenge to surgeons and oncologists. Some function as chemoreceptors, others are endocrinologically active. Familial paragangliomas are associated with mutations of the mitochondrial complex II genes.
| Language | Label | Description | Also known as |
|---|---|---|---|
| default for all languages | 2D11 |
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| English | Malignant neoplasms of adrenal gland |
Tumours arising from the adrenal cortex include adenomas and carcinomas. These are rare neoplasms but may cause a variety of hormonal symptoms, including hyperaldosteronism, Cushing syndrome, and virilisation. A small fraction of adrenocortical tumours are associated with an inherited tumour syndrome, including Li-Fraumeni syndrome and Carney complex. Benign and malignant phaeochromocytomas arise in the adrenal medulla and are derived from chromaffin cells of neural crest origin. Phaeochromocytomas may occur in the setting of several hereditary conditions, including multiple endocrine neoplasia types 2a and 2b, von Hippel Lindau disease and neurofibromatosis. Extra adrenal paragangliomas arise from chromaffin cells in sympathoadrenal and parasympathetic paraganglia. They occur in many parts of the body and can pose a significant challenge to surgeons and oncologists. Some function as chemoreceptors, others are endocrinologically active. Familial paragangliomas are associated with mutations of the mitochondrial complex II genes. |
