Autosomal dominant spastic paraplegia type 6 (Q100874): Difference between revisions

Autosomal dominant spastic paraplegia that usually presents in late adolescence or early adulthood as a pure phenotype of lower limb spasticity with hyperreflexia and extensor plantar responses, as well as mild bladder disturbances and pes cavus. Rarely, it can present as a complex phenotype with additional manifestations including epilepsy, variable peripheral neuropathy and/or memory impairment.