Myelopathy due to lathyrism (Q97256): Difference between revisions
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Mielopatia pode estar relacionada ao consumo de legumes do grupo Lathyrus contendo grandes quantidades da neurotoxina análoga a glutamato ácido β-N-oxalil-α,β-diaminopropiônico (ODAP, também conhecido como beta-N-oxalil amino-L-alanina, ou BOAA). Esta toxina causa uma paraparesia espástica irreversível, mas não progressiva, associada a alterações degenerativas na medula espinal e envolve o neurônio motor superior, bem como as células do corno anterior. O exame físico mostra evidências de fraqueza do tipo do neurônio motor superior com espasticidade e hiperreflexia que causa um transtorno de marcha espástica. Sintomas autonômicos podem estar presentes com disfunção da bexiga e intestino. Sintomas sensitivos subjetivos podem estar presentes, embora os achados sensitivos objetivos sejam incomuns. O início é frequentemente repentino e a fase aguda da doença pode durar por um mês. A condição pode ser prevalente durante fome e guerra, pois a leguminosa é uma planta resistente que pode sobreviver em condições difíceis. A doença agora só é vista em poucos países, incluindo Índia, Etiópia, Bangladesh e Nepal. | |||
| description / en | description / en | ||
Myelopathy can be related to the consumption of Lathyrus group of legumes containing large amounts of Glutamate analogue neurotoxin ?-oxalyl-L-?,?-diaminopropionic acid (ODAP, also known as ?-N-oxalyl-amino-L-alanine, or BOAA). This toxin causes an irreversible, but nonprogressive spastic paraparesis associated with degenerative changes in the spinal cord and involves the upper motor neuron as well as the anterior horn cells. Examination shows evidence of an upper motor neuron type of weakness with spasticity and hyperreflexia that causes a spastic gait disorder. Autonomic symptoms may be present with bladder and bowel dysfunction. Subjective sensory symptoms may be present, although objective sensory findings are unusual. The onset is often sudden and the acute phase of the disease may last for a month. The condition can be prevalent during famine and war as the legume is a hardy plant which can survive in difficult conditions. The disease is now only seen in few countries including India, Ethiopia, Bangladesh and Nepal. | |||
Revision as of 13:20, 16 August 2026
Myelopathy can be related to the consumption of Lathyrus group of legumes containing large amounts of Glutamate analogue neurotoxin ?-oxalyl-L-?,?-diaminopropionic acid (ODAP, also known as ?-N-oxalyl-amino-L-alanine, or BOAA). This toxin causes an irreversible, but nonprogressive spastic paraparesis associated with degenerative changes in the spinal cord and involves the upper motor neuron as well as the anterior horn cells. Examination shows evidence of an upper motor neuron type of weakness with spasticity and hyperreflexia that causes a spastic gait disorder. Autonomic symptoms may be present with bladder and bowel dysfunction. Subjective sensory symptoms may be present, although objective sensory findings are unusual. The onset is often sudden and the acute phase of the disease may last for a month. The condition can be prevalent during famine and war as the legume is a hardy plant which can survive in difficult conditions. The disease is now only seen in few countries including India, Ethiopia, Bangladesh and Nepal.
| Language | Label | Description | Also known as |
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| default for all languages | ID_925836811 |
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| English | Myelopathy due to lathyrism |
Myelopathy can be related to the consumption of Lathyrus group of legumes containing large amounts of Glutamate analogue neurotoxin ?-oxalyl-L-?,?-diaminopropionic acid (ODAP, also known as ?-N-oxalyl-amino-L-alanine, or BOAA). This toxin causes an irreversible, but nonprogressive spastic paraparesis associated with degenerative changes in the spinal cord and involves the upper motor neuron as well as the anterior horn cells. Examination shows evidence of an upper motor neuron type of weakness with spasticity and hyperreflexia that causes a spastic gait disorder. Autonomic symptoms may be present with bladder and bowel dysfunction. Subjective sensory symptoms may be present, although objective sensory findings are unusual. The onset is often sudden and the acute phase of the disease may last for a month. The condition can be prevalent during famine and war as the legume is a hardy plant which can survive in difficult conditions. The disease is now only seen in few countries including India, Ethiopia, Bangladesh and Nepal. |
