Keshan disease due to selenium deficiency (Q94473): Difference between revisions
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A doença de Keshan é uma doença endêmica em crianças de 2 a 10 anos e mulheres em idade reprodutiva que vivem em áreas do Nordeste e do Sudoeste da China. As manifestações típicas são fadiga mesmo após exercícios leves, arritmia cardíaca e palpitações, perda de apetite, insuficiência cardíaca, cardiomegalia e insuficiência cardíaca congestiva. As alterações patológicas incluem necrose miocárdica multifocal e fibrose. As artérias coronárias essencialmente não são afetadas. A doença tem uma acentuada flutuação sazonal na incidência e pode aparecer após apenas 3 meses de exposição a condições em localidades conhecidas por estarem associadas a um alto risco de miocardite. Uma vez estabelecida a doença, o selênio tem pouco ou nenhum valor terapêutico. No entanto, a profilaxia, que consiste na administração oral de selênio 3 meses antes dos períodos de maior risco previsto, é altamente eficaz. | |||
| description / en | description / en | ||
Keshan disease is an endemic condition in children aged 2–10 years and women of childbearing age living in areas from Northeast and Southwest China. Typical manifestations are fatigue after even mild exercise, cardiac arrhythmia and palpitations, loss of appetite, cardiac insufficiency, cardiomegaly, and congestive heart failure. Pathological changes include a multifocal myocardial necrosis and fibrosis. The coronary arteries are essentially unaffected. The disease has a marked seasonal fluctuation in incidence and may appear after only 3 months exposure to conditions in localities known to be associated with a high risk of myocarditis. Once the disease is established, selenium is of little or no therapeutic value. However, prophylaxis consisting of oral administration of selenium 3 months before the periods of highest anticipated risk is highly effective. | |||
Revision as of 09:37, 16 August 2026
Keshan disease is an endemic condition in children aged 2–10 years and women of childbearing age living in areas from Northeast and Southwest China. Typical manifestations are fatigue after even mild exercise, cardiac arrhythmia and palpitations, loss of appetite, cardiac insufficiency, cardiomegaly, and congestive heart failure. Pathological changes include a multifocal myocardial necrosis and fibrosis. The coronary arteries are essentially unaffected. The disease has a marked seasonal fluctuation in incidence and may appear after only 3 months exposure to conditions in localities known to be associated with a high risk of myocarditis. Once the disease is established, selenium is of little or no therapeutic value. However, prophylaxis consisting of oral administration of selenium 3 months before the periods of highest anticipated risk is highly effective.
| Language | Label | Description | Also known as |
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| default for all languages | ID_1307765114 |
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| English | Keshan disease due to selenium deficiency |
Keshan disease is an endemic condition in children aged 2–10 years and women of childbearing age living in areas from Northeast and Southwest China. Typical manifestations are fatigue after even mild exercise, cardiac arrhythmia and palpitations, loss of appetite, cardiac insufficiency, cardiomegaly, and congestive heart failure. Pathological changes include a multifocal myocardial necrosis and fibrosis. The coronary arteries are essentially unaffected. The disease has a marked seasonal fluctuation in incidence and may appear after only 3 months exposure to conditions in localities known to be associated with a high risk of myocarditis. Once the disease is established, selenium is of little or no therapeutic value. However, prophylaxis consisting of oral administration of selenium 3 months before the periods of highest anticipated risk is highly effective. |
