Necrotising polymyositis (Q90737): Difference between revisions
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| description / pt-br | description / pt-br | ||
Polimiosite necrosante é um transtorno muscular inflamatório, imune caracterizado por níveis elevados de CK, fraqueza muscular moderada a grave de início agudo ou subagudo, e com características histológicas de necrose da fibra muscular mediada por macrófagos como principal célula efetora. Não há infiltrados de células T ou expressão de MHC-I. No entanto, alguns pacientes têm anticorpos contra partículas de reconhecimento de sinal (SRP). A doença é multifatorial: câncer, infecção viral, uso de estatinas, exposição a agentes tóxicos ou processo autoimune subjacente; outros não têm outra doença ou exposição aparente a agentes exógenos. | |||
| description / en | description / en | ||
Necrotising polymyositis is an immune inflammatory muscle disorders characterised by high CK level, moderate to severe muscle weakness of acute or subacute onset and with histological features of muscle fibre necrosis mediated by macrophages as the main effector cell. There are no T cell infiltrates or MHC-I expression. However, some patients have antibodies against signal recognition particles (SRP). The disease is multifactorial: cancer, viral infection, use of statins, exposure to toxic agents, or underlying autoimmune process; others have no other disease or apparent exposure to exogenous agents. | |||
Revision as of 17:43, 15 August 2026
Necrotising polymyositis is an immune inflammatory muscle disorders characterised by high CK level, moderate to severe muscle weakness of acute or subacute onset and with histological features of muscle fibre necrosis mediated by macrophages as the main effector cell. There are no T cell infiltrates or MHC-I expression. However, some patients have antibodies against signal recognition particles (SRP). The disease is multifactorial: cancer, viral infection, use of statins, exposure to toxic agents, or underlying autoimmune process; others have no other disease or apparent exposure to exogenous agents.
| Language | Label | Description | Also known as |
|---|---|---|---|
| default for all languages | ID_194675725 |
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| English | Necrotising polymyositis |
Necrotising polymyositis is an immune inflammatory muscle disorders characterised by high CK level, moderate to severe muscle weakness of acute or subacute onset and with histological features of muscle fibre necrosis mediated by macrophages as the main effector cell. There are no T cell infiltrates or MHC-I expression. However, some patients have antibodies against signal recognition particles (SRP). The disease is multifactorial: cancer, viral infection, use of statins, exposure to toxic agents, or underlying autoimmune process; others have no other disease or apparent exposure to exogenous agents. |
