Late chronic graft-versus-host disease (Q88777): Difference between revisions
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Doença do enxerto-versus-hospedeiro (GVHD) crônica tardia usualmente se apresenta entre 150 e 300 dias após o transplante. Pode se desenvolver a partir da forma liquenoide crônica precoce da GVHD ou pode surgir como manifestação nova. É caracterizada por líquen escleroso disseminado ou por espessamento da pele semelhante à morfeia e poiquilodermia. Bolhas, erosões, alopecia, cicatrizes conjuntivais e, eventualmente, fibroses profundas com contraturas articulares podem ocorrer. O quadro pode ser acompanhado de fibrose de outros órgãos, incluindo pulmão e fígado. GVHD crônica tardia pode causar morbidade significativa, desfiguração e incapacidade. | |||
| description / en | description / en | ||
Late chronic-graft-versus-host disease (GVHD) usually presents between 150 and 300 days after engraftment. It may develop from the early chronic lichenoid form of GVHD or may arise de novo. It is characterised by widespread lichen sclerosus or morphoea-like thickening of the skin and poikiloderma. Blisters, erosions, alopecia, conjunctival scarring and, eventually, deep fibrosis with joint contractures may occur. These may be accompanied by fibrosis of other organs including lung and liver. Late chronic GVHD can result in considerable morbidity, disfigurement and disability. | |||
Revision as of 15:10, 15 August 2026
Late chronic-graft-versus-host disease (GVHD) usually presents between 150 and 300 days after engraftment. It may develop from the early chronic lichenoid form of GVHD or may arise de novo. It is characterised by widespread lichen sclerosus or morphoea-like thickening of the skin and poikiloderma. Blisters, erosions, alopecia, conjunctival scarring and, eventually, deep fibrosis with joint contractures may occur. These may be accompanied by fibrosis of other organs including lung and liver. Late chronic GVHD can result in considerable morbidity, disfigurement and disability.
| Language | Label | Description | Also known as |
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| default for all languages | ID_643345953 |
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| English | Late chronic graft-versus-host disease |
Late chronic-graft-versus-host disease (GVHD) usually presents between 150 and 300 days after engraftment. It may develop from the early chronic lichenoid form of GVHD or may arise de novo. It is characterised by widespread lichen sclerosus or morphoea-like thickening of the skin and poikiloderma. Blisters, erosions, alopecia, conjunctival scarring and, eventually, deep fibrosis with joint contractures may occur. These may be accompanied by fibrosis of other organs including lung and liver. Late chronic GVHD can result in considerable morbidity, disfigurement and disability. |
