Paraneoplastic movement disorder (Q84155): Difference between revisions
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Os transtornos do movimento paraneoplásico resultam de um ataque direcionado ao sistema nervoso central como consequência de uma resposta imune tumoral potencialmente eficaz iniciada por antígenos onco-neurais derivados de um câncer sistêmico. Eles são tipicamente subagudos, precedem a detecção do câncer e podem ser hipocinéticos (parkinsonismo [acinesia, bradicinesia, rigidez ou instabilidade postural]) ou hipercinéticos (coreia, tremor [núcleos cerebelares / basais associados], distonia ou mioclonia). As investigações podem revelar anormalidades de ressonância magnética nos gânglios da base e um fluido cefalorraquiano inflamatório. O perfil de autoanticorpos neurais no soro ou líquido cefalorraquidiano prediz o tipo de câncer [definição positiva de distúrbios do movimento paraneoplásico de autoanticorpos neurais]. | |||
| description / en | description / en | ||
Paraneoplastic movement disorders results from a targeted attack on the central nervous system as a consequence of a potentially effective tumour immune response initiated by onco-neural antigens derived from a systemic cancer. They are typically subacute, precede cancer detection and may be hypokinetic (parkinsonism [akinesia, bradykinesia, rigidity or postural instability]) or hyperkinetic (chorea, tremor [cerebellar/basal ganglia associated], dystonia or myoclonus). Investigations may reveal MRI abnormalities in the basal ganglia and an inflammatory spinal fluid. The neural autoantibody profile in the serum or cerebrospinal fluid predicts the cancer type [paraneoplastic movement disorders neural autoantibody positive definition]. | |||
Revision as of 09:31, 15 August 2026
Paraneoplastic movement disorders results from a targeted attack on the central nervous system as a consequence of a potentially effective tumour immune response initiated by onco-neural antigens derived from a systemic cancer. They are typically subacute, precede cancer detection and may be hypokinetic (parkinsonism [akinesia, bradykinesia, rigidity or postural instability]) or hyperkinetic (chorea, tremor [cerebellar/basal ganglia associated], dystonia or myoclonus). Investigations may reveal MRI abnormalities in the basal ganglia and an inflammatory spinal fluid. The neural autoantibody profile in the serum or cerebrospinal fluid predicts the cancer type [paraneoplastic movement disorders neural autoantibody positive definition].
| Language | Label | Description | Also known as |
|---|---|---|---|
| default for all languages | ID_1859516177 |
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| English | Paraneoplastic movement disorder |
Paraneoplastic movement disorders results from a targeted attack on the central nervous system as a consequence of a potentially effective tumour immune response initiated by onco-neural antigens derived from a systemic cancer. They are typically subacute, precede cancer detection and may be hypokinetic (parkinsonism [akinesia, bradykinesia, rigidity or postural instability]) or hyperkinetic (chorea, tremor [cerebellar/basal ganglia associated], dystonia or myoclonus). Investigations may reveal MRI abnormalities in the basal ganglia and an inflammatory spinal fluid. The neural autoantibody profile in the serum or cerebrospinal fluid predicts the cancer type [paraneoplastic movement disorders neural autoantibody positive definition]. |
