Nephrogenic diabetes insipidus (Q44717): Difference between revisions

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Diabetes insípido nefrogênico é uma condição na qual os túbulos renais respondem mal ao hormônio antidiurético secretado pela hipófise, resultando em falha na concentração da urina e perda de água. Poliúria com urina diluída e polidipsia (sede excessiva) estão presentes. Pode ser congênita ou adquirida por várias causas. As formas congênitas podem ser atribuídas a defeitos no receptor da vasopressina ou da aquaporina-2. Eles são caracterizados por poliúria com polidipsia, episódios recorrentes de picos de febre, constipação e desidratação hipernatrêmica aguda após o nascimento, e que podem causar sequelas neurológicas.
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Nephrogenic diabetes insipidus is a condition in which the kidney tubules respond poorly to pituitary secreted anti-diuretic hormone, resulting in a failure to concentrate the urine, and water loss. Polyuria with dilute urine and polydypsia (excessive thirst) are present. It can be congenital or acquired with many causes. The congenital forms may be attributed to vasopressin receptor or aquaporin-2 defects. They are characterised by polyuria with polydipsia, recurrent bouts of fever, constipation, and acute hypernatraemic dehydration after birth that may cause neurological sequelae.

Revision as of 12:19, 13 August 2026

Nephrogenic diabetes insipidus is a condition in which the kidney tubules respond poorly to pituitary secreted anti-diuretic hormone, resulting in a failure to concentrate the urine, and water loss. Polyuria with dilute urine and polydypsia (excessive thirst) are present. It can be congenital or acquired with many causes. The congenital forms may be attributed to vasopressin receptor or aquaporin-2 defects. They are characterised by polyuria with polydipsia, recurrent bouts of fever, constipation, and acute hypernatraemic dehydration after birth that may cause neurological sequelae.
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    Nephrogenic diabetes insipidus
    Nephrogenic diabetes insipidus is a condition in which the kidney tubules respond poorly to pituitary secreted anti-diuretic hormone, resulting in a failure to concentrate the urine, and water loss. Polyuria with dilute urine and polydypsia (excessive thirst) are present. It can be congenital or acquired with many causes. The congenital forms may be attributed to vasopressin receptor or aquaporin-2 defects. They are characterised by polyuria with polydipsia, recurrent bouts of fever, constipation, and acute hypernatraemic dehydration after birth that may cause neurological sequelae.

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