Anti-glomerular basement membrane antibody mediated disease (Q44664): Difference between revisions
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A glomerulonefrite mediada por anti-MBG é uma doença glomerular proliferativa focal e segmentar agressiva caracterizada por coloração linear da membrana basal glomerular para imunoglobulinas, particularmente IgG e IgM. Alterações crescênticas estão frequentemente associadas e os anticorpos circulantes contra membrana basal glomerular são encontrados na doença ativa. A síndrome renal costuma ser nefrite aguda com declínio funcional renal rápido (nefrite rapidamente progressiva) e, se associada a envolvimento respiratório (hemoptise, insuficiência respiratória), o conjunto é denominado "síndrome de Goodpasture" | |||
| description / en | description / en | ||
Anti-GBM mediated glomerulonephritis is an aggressive focal and segmental proliferative glomerular disease characterised by linear staining of the glomerular basement membrane for immunoglobulins, particularly IgG and IgM. Crescentic change is often associated and circulating anti-bodies to glomerular basement membrane are found in active disease. The renal syndrome is often acute nephritis with rapid renal functional decline (rapidly progressive nephritis) and if associated with respiratory involvement (haemoptysis, respiratory failure) the couple is termed “Goodpasture's syndrome”. | |||
Revision as of 12:14, 13 August 2026
Anti-GBM mediated glomerulonephritis is an aggressive focal and segmental proliferative glomerular disease characterised by linear staining of the glomerular basement membrane for immunoglobulins, particularly IgG and IgM. Crescentic change is often associated and circulating anti-bodies to glomerular basement membrane are found in active disease. The renal syndrome is often acute nephritis with rapid renal functional decline (rapidly progressive nephritis) and if associated with respiratory involvement (haemoptysis, respiratory failure) the couple is termed “Goodpasture's syndrome”.
| Language | Label | Description | Also known as |
|---|---|---|---|
| default for all languages | MF85 |
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| English | Anti-glomerular basement membrane antibody mediated disease |
Anti-GBM mediated glomerulonephritis is an aggressive focal and segmental proliferative glomerular disease characterised by linear staining of the glomerular basement membrane for immunoglobulins, particularly IgG and IgM. Crescentic change is often associated and circulating anti-bodies to glomerular basement membrane are found in active disease. The renal syndrome is often acute nephritis with rapid renal functional decline (rapidly progressive nephritis) and if associated with respiratory involvement (haemoptysis, respiratory failure) the couple is termed “Goodpasture's syndrome”. |
