Paraneoplastic polymyositis (Q44383): Difference between revisions
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Paraneoplasia é uma entidade rara associada ao câncer. Apresenta-se de forma subaguda ou aguda como fraqueza proximal, muitas vezes incluindo os flexores do pescoço, disfagia, raramente envolvendo os músculos respiratórios e o coração. Às vezes, ocorre dor muscular ou mialgia. A histopatologia muscular mostra uma toxicidade linfocitária mediada por células contra as fibras musculares em áreas focais de inflamação no tecido conjuntivo perimisial e nos vasos sanguíneos circundantes. As fibras musculares podem ser destruídas por células T citotóxicas._x000D_ Linfoma não-Hodgkin, carcinoma de pulmão e bexiga são os tipos de câncer associados mais frequentemente observados. | |||
| description / en | description / en | ||
Paraneoplastic is a rare cancer associated entity. It presents sub-, or acutely with proximal weakness, often including the neck flexors, dysphagia, rarely the respiratory muscles and the heart are involved. Sometimes muscle pain or myalgia occur. Myopathology shows a targeted, cell-mediated lymphocyte toxicity against muscle fibres in focal areas of inflammation within perimysial connective tissue and surrounding blood vessels. Muscle fibres may be destroyed by cytotoxic T cells. Non-Hodgkin’s lymphoma, lung, and bladder carcinoma are the most frequently observed associated cancer types. | |||
Revision as of 11:49, 13 August 2026
Paraneoplastic is a rare cancer associated entity. It presents sub-, or acutely with proximal weakness, often including the neck flexors, dysphagia, rarely the respiratory muscles and the heart are involved. Sometimes muscle pain or myalgia occur. Myopathology shows a targeted, cell-mediated lymphocyte toxicity against muscle fibres in focal areas of inflammation within perimysial connective tissue and surrounding blood vessels. Muscle fibres may be destroyed by cytotoxic T cells. Non-Hodgkin’s lymphoma, lung, and bladder carcinoma are the most frequently observed associated cancer types.
| Language | Label | Description | Also known as |
|---|---|---|---|
| default for all languages | 4A41.11 |
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| English | Paraneoplastic polymyositis |
Paraneoplastic is a rare cancer associated entity. It presents sub-, or acutely with proximal weakness, often including the neck flexors, dysphagia, rarely the respiratory muscles and the heart are involved. Sometimes muscle pain or myalgia occur. Myopathology shows a targeted, cell-mediated lymphocyte toxicity against muscle fibres in focal areas of inflammation within perimysial connective tissue and surrounding blood vessels. Muscle fibres may be destroyed by cytotoxic T cells. Non-Hodgkin’s lymphoma, lung, and bladder carcinoma are the most frequently observed associated cancer types. |
