Non-alcoholic steatohepatitis (Q43616): Difference between revisions
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Esteatohepatite não alcoólica (NASH) é a forma histológica de doença hepática gordurosa não alcoólica (DHGNA) em que as características principais são a evidência histológica de lesão de hepatócitos (como a balonização ou alteração hialina de Mallory) e inflamação lobular importante. NASH está frequentemente associada a fibrose de distribuição pericentral e perissinusoidal (um padrão de fibrose portal também existe, particularmente em crianças). NASH é a forma clinicamente progressiva da DHGNA com desfechos clínicos que incluem eventos cardiovasculares e cirrose ou carcinoma hepatocelular. Embora novos biomarcadores para NASH tenham sido relatados, a histologia continua sendo o padrão-ouro para o diagnóstico. | |||
| description / en | description / en | ||
Non-alcoholic steatohepatitis (NASH) is a histological form of Non-alcoholic fatty liver disease (NAFLD) in which the key features are histological evidence of hepatocyte injury (such as ballooning or Mallory hyaline) and substantial lobular inflammation. NASH is often associated with fibrosis in pericentral and perisinusoidal distribution (a portal fibrosis pattern also exists, particularly in children). NASH is the clinically progressive form of NAFLD with clinical outcomes including cardiovascular events, and cirrhosis or hepatocellular carcinoma. While novel biomarkers for NASH have been reported, histology remains the gold standard for diagnosis. | |||
Revision as of 10:42, 13 August 2026
Non-alcoholic steatohepatitis (NASH) is a histological form of Non-alcoholic fatty liver disease (NAFLD) in which the key features are histological evidence of hepatocyte injury (such as ballooning or Mallory hyaline) and substantial lobular inflammation. NASH is often associated with fibrosis in pericentral and perisinusoidal distribution (a portal fibrosis pattern also exists, particularly in children). NASH is the clinically progressive form of NAFLD with clinical outcomes including cardiovascular events, and cirrhosis or hepatocellular carcinoma. While novel biomarkers for NASH have been reported, histology remains the gold standard for diagnosis.
| Language | Label | Description | Also known as |
|---|---|---|---|
| default for all languages | DB92.1 |
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| English | Non-alcoholic steatohepatitis |
Non-alcoholic steatohepatitis (NASH) is a histological form of Non-alcoholic fatty liver disease (NAFLD) in which the key features are histological evidence of hepatocyte injury (such as ballooning or Mallory hyaline) and substantial lobular inflammation. NASH is often associated with fibrosis in pericentral and perisinusoidal distribution (a portal fibrosis pattern also exists, particularly in children). NASH is the clinically progressive form of NAFLD with clinical outcomes including cardiovascular events, and cirrhosis or hepatocellular carcinoma. While novel biomarkers for NASH have been reported, histology remains the gold standard for diagnosis. |
