Calcific arteriolopathy (Q42584): Difference between revisions
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Arteriolopatia calcificada (calcifilaxia) é um transtorno vasculopático potencialmente fatal caracterizada por isquemia cutânea dolorosa e infarto devido a calcificação, fibroplasia intimal e trombose de arteríolas subcutâneas. É mais comumente associada a doença renal em estágio terminal ou transplante renal, particularmente no contexto de diabetes mellitus de longa data. A pele afetada, comumente em quadris e coxas, aparece mosqueada, cinza e desvitalizada antes de progredir para infarto de espessura total e ulceração profunda. Estas alterações podem ser acompanhadas por placas subcutâneas enduradas, indicando uma paniculite calcificante subjacente. A condição pode estar, mas nem sempre está, associada a hiperparatireoidismo ou a um produto cálcio-fosfato elevado. | |||
| description / en | description / en | ||
Calcific arteriolopathy (calciphylaxis) is a life-threatening vasculopathic disorder characterised by painful cutaneous ischaemia and infarction due to calcification, intimal fibroplasia, and thrombosis of subcutaneous arterioles. It is most commonly associated with end-stage kidney disease or renal transplantation, particularly in the context of longstanding diabetes mellitus. Affected skin, commonly on the hips and thighs, appears mottled, grey and devitalized before progressing to full thickness infarction and deep ulceration. These changes may be accompanied by indurated subcutaneous plaques indicating an underlying calcifying panniculitis. The condition may be but is not always associated with hyperparathyroidism or an elevated calcium-phosphate product. | |||
Revision as of 09:10, 13 August 2026
Calcific arteriolopathy (calciphylaxis) is a life-threatening vasculopathic disorder characterised by painful cutaneous ischaemia and infarction due to calcification, intimal fibroplasia, and thrombosis of subcutaneous arterioles. It is most commonly associated with end-stage kidney disease or renal transplantation, particularly in the context of longstanding diabetes mellitus. Affected skin, commonly on the hips and thighs, appears mottled, grey and devitalized before progressing to full thickness infarction and deep ulceration. These changes may be accompanied by indurated subcutaneous plaques indicating an underlying calcifying panniculitis. The condition may be but is not always associated with hyperparathyroidism or an elevated calcium-phosphate product.
| Language | Label | Description | Also known as |
|---|---|---|---|
| default for all languages | EB90.42 |
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| English | Calcific arteriolopathy |
Calcific arteriolopathy (calciphylaxis) is a life-threatening vasculopathic disorder characterised by painful cutaneous ischaemia and infarction due to calcification, intimal fibroplasia, and thrombosis of subcutaneous arterioles. It is most commonly associated with end-stage kidney disease or renal transplantation, particularly in the context of longstanding diabetes mellitus. Affected skin, commonly on the hips and thighs, appears mottled, grey and devitalized before progressing to full thickness infarction and deep ulceration. These changes may be accompanied by indurated subcutaneous plaques indicating an underlying calcifying panniculitis. The condition may be but is not always associated with hyperparathyroidism or an elevated calcium-phosphate product. |
