Autoimmune myopathy (Q41407): Difference between revisions
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A miopatia autoimune é um subgrupo de miopatias inflamatórias idiopáticas que, apesar de terem diversas causas, apresentam as características histopatológicas comuns de necrose de miócitos sem inflamação significativa. Os pacientes apresentam uma miopatia proximal simétrica grave subaguda, associada a um nível de creatinoquinase acentuadamente elevado. Eles são mais provavelmente imunomediados, pois respondem à imunoterapia. É frequentemente acompanhada por terapia com estatinas, doenças do tecido conjuntivo, câncer e autoanticorpos específicos para partícula de reconhecimento de sinal (SRP) ou 3-hidroxi-3-metilglutaril-coenzima A redutase (HMGCR). | |||
| description / en | description / en | ||
Autoimmune myopathy is a subgroup of idiopathic inflammatory myopathies, which, despite diverse causes, have the common histopathological features of myocyte necrosis without significant inflammation. Patients present with a subacute severe symmetrical proximal myopathy, associated with a markedly elevated creatine kinase level. These are most likely immune-mediated, as they respond to immunotherapy. It is often accompanied by statin therapy, connective tissue diseases, cancer, and autoantibodies specific for signal recognition particle (SRP) or 3-hydroxy-3-methylglutaryl–coenzyme A reductase (HMGCR). | |||
Revision as of 07:34, 13 August 2026
Autoimmune myopathy is a subgroup of idiopathic inflammatory myopathies, which, despite diverse causes, have the common histopathological features of myocyte necrosis without significant inflammation. Patients present with a subacute severe symmetrical proximal myopathy, associated with a markedly elevated creatine kinase level. These are most likely immune-mediated, as they respond to immunotherapy. It is often accompanied by statin therapy, connective tissue diseases, cancer, and autoantibodies specific for signal recognition particle (SRP) or 3-hydroxy-3-methylglutaryl–coenzyme A reductase (HMGCR).
| Language | Label | Description | Also known as |
|---|---|---|---|
| default for all languages | 8C81 |
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| English | Autoimmune myopathy |
Autoimmune myopathy is a subgroup of idiopathic inflammatory myopathies, which, despite diverse causes, have the common histopathological features of myocyte necrosis without significant inflammation. Patients present with a subacute severe symmetrical proximal myopathy, associated with a markedly elevated creatine kinase level. These are most likely immune-mediated, as they respond to immunotherapy. It is often accompanied by statin therapy, connective tissue diseases, cancer, and autoantibodies specific for signal recognition particle (SRP) or 3-hydroxy-3-methylglutaryl–coenzyme A reductase (HMGCR). |
