Folate deficiency (Q39926): Difference between revisions
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A deficiência nutricional de folato é comum nas pessoas com dieta limitada. Isso pode ser exacerbado por condições de má absorção, incluindo doença celíaca e espru tropical. Mulheres grávidas correm o risco de deficiência de folato pois a gravidez aumenta significativamente a necessidade deste componente, especialmente durante os períodos de rápido crescimento fetal (segundo e terceiro trimestres). Durante a lactação, as perdas de folato no leite também aumentam a necessidade de folato. Durante a gravidez, há um risco aumentado de defeitos do tubo neural fetal (DTN), com o risco aumentando 10 vezes à medida que o nível de folato passa de adequado para deficiente. No período correspondente a 21 até 27 dias pós-concepção, a placa neural se fecha para formar o que acabará sendo a medula espinhal e o crânio. A espinha bífida, a anencefalia e outras condições semelhantes são denominadas coletivamente de DTN. Eles resultam do fechamento impróprio da medula espinhal e do crânio, respectivamente, e são as anormalidades congênitas mais comuns associadas à deficiência de folato. | |||
| description / en | description / en | ||
Nutritional deficiency of folate is common in people consuming a limited diet. This can be exacerbated by malabsorption conditions, including coeliac disease and tropical sprue. Pregnant women are at risk for folate deficiency because pregnancy significantly increases the folate requirement, especially during periods of rapid fetal growth (i.e. in the second and third trimester). During lactation, losses of folate in milk also increase the folate requirement. During pregnancy, there is an increased risk of fetal neural tube defects (NTDs), with risk increasing 10-fold as folate status goes from adequate to poor. Between days 21 and 27 post-conception, the neural plate closes to form what will eventually be the spinal cord and cranium. Spina bifida, anencephaly, and other similar conditions are collectively called NTDs. They result from improper closure of the spinal cord and cranium, respectively, and are the most common congenital abnormalities associated with folate deficiency. | |||
Revision as of 05:32, 13 August 2026
Nutritional deficiency of folate is common in people consuming a limited diet. This can be exacerbated by malabsorption conditions, including coeliac disease and tropical sprue. Pregnant women are at risk for folate deficiency because pregnancy significantly increases the folate requirement, especially during periods of rapid fetal growth (i.e. in the second and third trimester). During lactation, losses of folate in milk also increase the folate requirement. During pregnancy, there is an increased risk of fetal neural tube defects (NTDs), with risk increasing 10-fold as folate status goes from adequate to poor. Between days 21 and 27 post-conception, the neural plate closes to form what will eventually be the spinal cord and cranium. Spina bifida, anencephaly, and other similar conditions are collectively called NTDs. They result from improper closure of the spinal cord and cranium, respectively, and are the most common congenital abnormalities associated with folate deficiency.
| Language | Label | Description | Also known as |
|---|---|---|---|
| default for all languages | 5B5E |
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| English | Folate deficiency |
Nutritional deficiency of folate is common in people consuming a limited diet. This can be exacerbated by malabsorption conditions, including coeliac disease and tropical sprue. Pregnant women are at risk for folate deficiency because pregnancy significantly increases the folate requirement, especially during periods of rapid fetal growth (i.e. in the second and third trimester). During lactation, losses of folate in milk also increase the folate requirement. During pregnancy, there is an increased risk of fetal neural tube defects (NTDs), with risk increasing 10-fold as folate status goes from adequate to poor. Between days 21 and 27 post-conception, the neural plate closes to form what will eventually be the spinal cord and cranium. Spina bifida, anencephaly, and other similar conditions are collectively called NTDs. They result from improper closure of the spinal cord and cranium, respectively, and are the most common congenital abnormalities associated with folate deficiency. |
