Chronic lymphocytic leukaemia of B-cell type (Q39161): Difference between revisions
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A leucemia linfocítica crônica / linfoma linfocítico de pequenas células (LLC/LLPC) é uma neoplasia composta por linfócitos B monomórficos pequenos, arredondados a ligeiramente irregulares no sangue periférico, medula óssea, baço e linfonodos, misturados com prolinfócitos e paraimunoblastos formando centros proliferativos nos infiltrados teciduais. As células LLC/LLPC geralmente coexpressam CD5 e CD23. Na ausência de envolvimento do tecido extramedular, deve haver linfócitos monoclonais ≤5x109/L com um fenótipo LLC no sangue periférico. O relatório do International Workshop on Chronic Lymphocytic Leukemia (IWCLL) determina que a linfocitose esteja presente por pelo menos 3 meses e também permite que o diagnóstico de CLL seja feito com contagens de linfócitos mais baixas em pacientes com citopenias ou sintomas relacionados à doença. Resta determinar se os pacientes que teriam preenchido os critérios no passado para LLC, mas que atendem aos critérios apenas para linfocitose B monoclonal (LBM), sejam considerados como tendo LLC ou LBM em estágio inicial. Alguns podem preferir ainda considerar muitos desses casos mais como LLC. O termo LLPC é usado para casos não leucêmicos com a morfologia do tecido e imunofenótipo de LLC. A definição IWCLL de LLPC requer linfadenopatia, sem citopenias devido à infiltração da medula óssea por LLC/LLPC e <5x109/L de células B no sangue periférico. | |||
| description / en | description / en | ||
Chronic lymphocytic leukaemia/small lymphocytic lymphoma (CLL/SLL) is a neoplasm composed of monomorphic small, round to slightly irregular B lymphocytes in the peripheral blood (PB), bone marrow (BM), spleen and lymph nodes, admixed with prolymphocytes and paraimmunoblasts forming proliferation centres in tissue infiltrates. The CLL/SLL cells usually coexpress CD5 and CD23. In the absence of extramedullary tissue involvement, there must be <5x109/L monoclonal lymphocytes with a CLL phenotype in the PB. The International Workshop on Chronic Lymphocytic Leukemia (IWCLL) report requires that the lymphocytosis be present for at least 3 months and also allows for the diagnosis of CLL to be made with lower lymphocyte counts in patients with cytopenias or disease-related symptoms. Whether patients who would have fulfilled the criteria in the past for CLL but who fulfill the criteria only for monoclonal B lymphocytosis (MBL) are better considered to have low stage CLL or MBL remains to be determined. Some may prefer to still consider many of these cases more like CLL. The term SLL is used for non-leukaemic cases with the tissue morphology and immunophenotype of CLL. The IWCLL definition of SLL requires lymphadenopathy, no cytopenias due to BM infiltration by CLL/SLL and <5x109/L PB B-cells. | |||
Revision as of 04:29, 13 August 2026
Chronic lymphocytic leukaemia/small lymphocytic lymphoma (CLL/SLL) is a neoplasm composed of monomorphic small, round to slightly irregular B lymphocytes in the peripheral blood (PB), bone marrow (BM), spleen and lymph nodes, admixed with prolymphocytes and paraimmunoblasts forming proliferation centres in tissue infiltrates. The CLL/SLL cells usually coexpress CD5 and CD23. In the absence of extramedullary tissue involvement, there must be <5x109/L monoclonal lymphocytes with a CLL phenotype in the PB. The International Workshop on Chronic Lymphocytic Leukemia (IWCLL) report requires that the lymphocytosis be present for at least 3 months and also allows for the diagnosis of CLL to be made with lower lymphocyte counts in patients with cytopenias or disease-related symptoms. Whether patients who would have fulfilled the criteria in the past for CLL but who fulfill the criteria only for monoclonal B lymphocytosis (MBL) are better considered to have low stage CLL or MBL remains to be determined. Some may prefer to still consider many of these cases more like CLL. The term SLL is used for non-leukaemic cases with the tissue morphology and immunophenotype of CLL. The IWCLL definition of SLL requires lymphadenopathy, no cytopenias due to BM infiltration by CLL/SLL and <5x109/L PB B-cells.
| Language | Label | Description | Also known as |
|---|---|---|---|
| default for all languages | 2A82.00 |
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| English | Chronic lymphocytic leukaemia of B-cell type |
Chronic lymphocytic leukaemia/small lymphocytic lymphoma (CLL/SLL) is a neoplasm composed of monomorphic small, round to slightly irregular B lymphocytes in the peripheral blood (PB), bone marrow (BM), spleen and lymph nodes, admixed with prolymphocytes and paraimmunoblasts forming proliferation centres in tissue infiltrates. The CLL/SLL cells usually coexpress CD5 and CD23. In the absence of extramedullary tissue involvement, there must be <5x109/L monoclonal lymphocytes with a CLL phenotype in the PB. The International Workshop on Chronic Lymphocytic Leukemia (IWCLL) report requires that the lymphocytosis be present for at least 3 months and also allows for the diagnosis of CLL to be made with lower lymphocyte counts in patients with cytopenias or disease-related symptoms. Whether patients who would have fulfilled the criteria in the past for CLL but who fulfill the criteria only for monoclonal B lymphocytosis (MBL) are better considered to have low stage CLL or MBL remains to be determined. Some may prefer to still consider many of these cases more like CLL. The term SLL is used for non-leukaemic cases with the tissue morphology and immunophenotype of CLL. The IWCLL definition of SLL requires lymphadenopathy, no cytopenias due to BM infiltration by CLL/SLL and <5x109/L PB B-cells. |
