Malignant neoplasms of liver or intrahepatic bile ducts (Q38678): Difference between revisions
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A neoplasia hepática mais frequente e importante é o carcinoma hepatocelular primário (CHC). Em muitas partes do mundo, em particular na África e na Ásia, representa uma carga significativa de doenças. Nessas regiões de alta incidência, a infecção crônica pelo vírus da hepatite B (VHB) é a principal causa subjacente, com exceção do Japão, que tem uma alta prevalência de infecção por hepatite C. A vacinação contra o VHB tornou-se uma ferramenta poderosa na redução da cirrose e do CHC, mas a implementação ainda é subótima em várias regiões de alto risco. Nos países ocidentais, o abuso crônico de álcool é um fator etiológico importante. O colangiocarcinoma hepático tem uma distribuição geográfica diferente, com pico de incidência no norte da Tailândia. Aqui, é causado por uma infecção crônica com a fascíola do fígado, Opisthorchis Viverrini, que é ingerida por meio de peixes crus infectados. | |||
| description / en | description / en | ||
The most frequent and important hepatic neoplasm is the primary hepatocellular carcinoma (HCC). In many parts of the world, in particular Africa and Asia, it poses a significant disease burden. In these high incidence regions, chronic infection with hepatitis B virus (HBV) is the principal underlying cause, with the exception of Japan which has a high prevalence of hepatitis C infection. HBV vaccination has become a powerful tool in reducing cirrhosis and HCC, but implementation is still suboptimal in several high risk regions. In Western countries, chronic alcohol abuse is a major aetiological factor. Hepatic cholangiocarcinoma has a different geographical distribution, with peak incidences in Northern Thailand. Here, it is caused by chronic infection with the liver fluke, Opisthorchis viverrini, which is ingested through infected raw fish. | |||
Revision as of 03:50, 13 August 2026
The most frequent and important hepatic neoplasm is the primary hepatocellular carcinoma (HCC). In many parts of the world, in particular Africa and Asia, it poses a significant disease burden. In these high incidence regions, chronic infection with hepatitis B virus (HBV) is the principal underlying cause, with the exception of Japan which has a high prevalence of hepatitis C infection. HBV vaccination has become a powerful tool in reducing cirrhosis and HCC, but implementation is still suboptimal in several high risk regions. In Western countries, chronic alcohol abuse is a major aetiological factor. Hepatic cholangiocarcinoma has a different geographical distribution, with peak incidences in Northern Thailand. Here, it is caused by chronic infection with the liver fluke, Opisthorchis viverrini, which is ingested through infected raw fish.
| Language | Label | Description | Also known as |
|---|---|---|---|
| default for all languages | 2C12 |
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| English | Malignant neoplasms of liver or intrahepatic bile ducts |
The most frequent and important hepatic neoplasm is the primary hepatocellular carcinoma (HCC). In many parts of the world, in particular Africa and Asia, it poses a significant disease burden. In these high incidence regions, chronic infection with hepatitis B virus (HBV) is the principal underlying cause, with the exception of Japan which has a high prevalence of hepatitis C infection. HBV vaccination has become a powerful tool in reducing cirrhosis and HCC, but implementation is still suboptimal in several high risk regions. In Western countries, chronic alcohol abuse is a major aetiological factor. Hepatic cholangiocarcinoma has a different geographical distribution, with peak incidences in Northern Thailand. Here, it is caused by chronic infection with the liver fluke, Opisthorchis viverrini, which is ingested through infected raw fish. |
