Von Willebrand disease type 2M (Q100614): Difference between revisions
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A doença de von Willebrand tipo 2M (DVW tipo 2M) é um subtipo de DVW tipo 2 caracterizada por um transtorno hemorrágico associado a uma redução da afinidade do fator de von Willebrand (FVW) pelas plaquetas e pelo subendotélio na ausência de qualquer deficiência de multímeros de FVW de alto peso molecular. A doença manifesta-se anomalias do sangramento mucocutâneo (menorragia, epistaxe, hemorragia gastrointestinal, etc.). A DVW tipo 2M é causada por mutações no gene do FVW, e a herança é autossômica dominante. | |||||||||||||||
| description / en | description / en | ||||||||||||||
Type 2M von Willebrand disease (type 2M VWD) is a subtype of type 2 VWD (see this term) characterised by a bleeding disorder associated with a decrease in the affinity of the Willebrand factor (von Willebrand factor; VWF) for platelets and the subendothelium in the absence of any deficiency of high molecular weight VWF multimers. The disease manifests as mucocutaneous bleeding anomalies (menorrhagia, epistaxis, gastrointestinal haemorrhage etc.). Type 2M VWD is caused by mutations in the VWF gene and transmission is autosomal dominant. | |||||||||||||||
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| Property / Canonical URI: https://id.who.int/icd/entity/1358085002 / rank | |||||||||||||||
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CID11:ID_1358085002 | |||||||||||||||
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dki-india-ID_1358085002 | |||||||||||||||
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| Property / Knowledge Architect: https://pauloleads.com.br/cases-publicos/ / rank | |||||||||||||||
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15 August 2026
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Latest revision as of 17:20, 16 August 2026
Type 2M von Willebrand disease (type 2M VWD) is a subtype of type 2 VWD (see this term) characterised by a bleeding disorder associated with a decrease in the affinity of the Willebrand factor (von Willebrand factor; VWF) for platelets and the subendothelium in the absence of any deficiency of high molecular weight VWF multimers. The disease manifests as mucocutaneous bleeding anomalies (menorrhagia, epistaxis, gastrointestinal haemorrhage etc.). Type 2M VWD is caused by mutations in the VWF gene and transmission is autosomal dominant.
| Language | Label | Description | Also known as |
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| default for all languages | ID_1358085002 |
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| English | Von Willebrand disease type 2M |
Type 2M von Willebrand disease (type 2M VWD) is a subtype of type 2 VWD (see this term) characterised by a bleeding disorder associated with a decrease in the affinity of the Willebrand factor (von Willebrand factor; VWF) for platelets and the subendothelium in the absence of any deficiency of high molecular weight VWF multimers. The disease manifests as mucocutaneous bleeding anomalies (menorrhagia, epistaxis, gastrointestinal haemorrhage etc.). Type 2M VWD is caused by mutations in the VWF gene and transmission is autosomal dominant. |
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CID11:ID_1358085002
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dki-india-ID_1358085002
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Concluído
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15 August 2026
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