POEMS syndrome (Q94853): Difference between revisions

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Latest revision as of 10:23, 16 August 2026

POEMS syndrome is defined by the presence of a peripheral neuropathy (P), a monoclonal plasma cell disorder (M), and other paraneoplastic features, the most common of which are organomegaly (O), endocrinopathy (E), skin changes (S), papilledema, edema, effusions, ascites, and thrombocytosis. Virtually all patients will have either at least one sclerotic bone lesion or concomitant Castleman disease. Associated neural autoantibodies are: Immunoglobulin G or Immunoglobulin A with lambda light chain, increased Vascular Endothelial Growth Factor (VEGF).

Language	Label	Description	Also known as
default for all languages	ID_1555299114
English	POEMS syndrome	POEMS syndrome is defined by the presence of a peripheral neuropathy (P), a monoclonal plasma cell disorder (M), and other paraneoplastic features, the most common of which are organomegaly (O), endocrinopathy (E), skin changes (S), papilledema, edema, effusions, ascites, and thrombocytosis. Virtually all patients will have either at least one sclerotic bone lesion or concomitant Castleman disease. Associated neural autoantibodies are: Immunoglobulin G or Immunoglobulin A with lambda light chain, increased Vascular Endothelial Growth Factor (VEGF).