Late-delayed brain irradiation (Q85136): Difference between revisions

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+Lesão cerebral que ocorre vários meses a anos após a irradiação craniana terapêutica e está associada a atrofia cerebral difusa, necrose focal da área irradiada e alteração vascular secundária. Patologicamente, existem alterações de desmielinização. As características clínicas da irradiação cerebral tardia incluem comprometimento cognitivo, demência, transtorno da marcha, disfunção hipotalâmica resultando em distúrbios endócrinos, neuropatia óptica e outras neuropatias cranianas e doenças vasculares. A incidência de efeitos tardios da radioterapia está relacionada à dose total de radiação e ao tamanho das doses fracionadas. O diagnóstico pode ser auxiliado por neuroimagem, incluindo imagens nucleares e biópsia cerebral.
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+Brain injury occurring several months to years following therapeutic cranial irradiation and is associated with diffuse cerebral atrophy, focal radiation necrosis and secondary vascular change. Pathologically, there are changes of demyelination. Clinical features of late-delayed brain irradiation include cognitive impairment, dementia, gait disturbance, hypothalamic dysfunction resulting in endocrine disturbances, optic neuropathy and other cranial neuropathies and vascular disease. The incidence of late-delayed radiotherapy effects is related to the total radiation dose and the size of fractionated doses. Diagnosis may be aided by neuroimaging including nuclear imaging and brain biopsy.
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Latest revision as of 10:29, 15 August 2026

Brain injury occurring several months to years following therapeutic cranial irradiation and is associated with diffuse cerebral atrophy, focal radiation necrosis and secondary vascular change. Pathologically, there are changes of demyelination. Clinical features of late-delayed brain irradiation include cognitive impairment, dementia, gait disturbance, hypothalamic dysfunction resulting in endocrine disturbances, optic neuropathy and other cranial neuropathies and vascular disease. The incidence of late-delayed radiotherapy effects is related to the total radiation dose and the size of fractionated doses. Diagnosis may be aided by neuroimaging including nuclear imaging and brain biopsy.

Language	Label	Description	Also known as
default for all languages	ID_562730231
English	Late-delayed brain irradiation	Brain injury occurring several months to years following therapeutic cranial irradiation and is associated with diffuse cerebral atrophy, focal radiation necrosis and secondary vascular change. Pathologically, there are changes of demyelination. Clinical features of late-delayed brain irradiation include cognitive impairment, dementia, gait disturbance, hypothalamic dysfunction resulting in endocrine disturbances, optic neuropathy and other cranial neuropathies and vascular disease. The incidence of late-delayed radiotherapy effects is related to the total radiation dose and the size of fractionated doses. Diagnosis may be aided by neuroimaging including nuclear imaging and brain biopsy.