Voltage-gated calcium channel-associated Lambert-Eaton myasthenic syndrome (Q96654): Difference between revisions

@@ description / pt-br / description / pt-br @@
+A síndrome miastênica de Lambert-Eaton é uma doença autoimune humana rara da junção neuromuscular causada pela presença de anticorpos dirigidos contra canais de cálcio voltagem dependentes localizados na membrana pré-sináptica de seus terminais nervosos motores, levando assim à redução da transmissão neuromuscular. Em aproximadamente 50% dos pacientes, a síndrome miastênica de Lambert-Eaton é refletida por uma manifestação paraneoplásica e mais comumente associada a um carcinoma pulmonar de células pequenas cujas células também expressam canais de cálcio voltagem dependentes em sua membrana plasmática.
@@ description / en / description / en @@
+Lambert-Eaton myasthenic syndrome is a rare human autoimmune disorder of the neuromuscular junction caused by the presence of antibodies directed against voltage-gated calcium channels localised in the presynaptic membrane of their motor nerve terminals, thus leading to reduced neuromuscular transmission. In approximately 50% of the patients, Lambert-Eaton myasthenic syndrome is reflected by a paraneoplastic manifestation and most commonly associated with a small cell lung carcinoma whose cells also express voltage-gated calcium channels in their plasma membrane.
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Latest revision as of 12:41, 16 August 2026

Lambert-Eaton myasthenic syndrome is a rare human autoimmune disorder of the neuromuscular junction caused by the presence of antibodies directed against voltage-gated calcium channels localised in the presynaptic membrane of their motor nerve terminals, thus leading to reduced neuromuscular transmission. In approximately 50% of the patients, Lambert-Eaton myasthenic syndrome is reflected by a paraneoplastic manifestation and most commonly associated with a small cell lung carcinoma whose cells also express voltage-gated calcium channels in their plasma membrane.

Language	Label	Description	Also known as
default for all languages	ID_97949388
English	Voltage-gated calcium channel-associated Lambert-Eaton myasthenic syndrome	Lambert-Eaton myasthenic syndrome is a rare human autoimmune disorder of the neuromuscular junction caused by the presence of antibodies directed against voltage-gated calcium channels localised in the presynaptic membrane of their motor nerve terminals, thus leading to reduced neuromuscular transmission. In approximately 50% of the patients, Lambert-Eaton myasthenic syndrome is reflected by a paraneoplastic manifestation and most commonly associated with a small cell lung carcinoma whose cells also express voltage-gated calcium channels in their plasma membrane.