Myasthenia gravis, seronegative (Q88656): Difference between revisions

@@ description / pt-br / description / pt-br @@
+Em aproximadamente 50% dos pacientes soronegativos para o receptor da acetilcolina com Miastenia Gravis generalizada (MG), nenhum autoanticorpo contra a quinase muscular específica (MuSK) ou contra AChRs pôde ser detectado por métodos de rotina. Neste grupo, autoanticorpos contra a proteína 4 relacionada ao receptor de lipoproteína de baixa densidade (LRP4) foram identificados no soro de vários destes pacientes com uma variação de frequência (7-32%). Existem também pacientes duplamente positivos (com LRP4 e AChR ou MuSK). Anticorpos anti-agrina foram detectados em combinação com autoanticorpos contra MuSK, LRP4 ou AChRs em 10-15% dos pacientes com MG generalizada.
@@ description / en / description / en @@
+In approximately 50% of the Acetylcholine receptor-seronegative patients with generalised Myasthenia Gravis (MG), no autoantibodies against Muscle-specific kinase (MuSK) or against AChRs could be detected by routine methods. In this group autoantibodies against the low-density lipoprotein receptor-related protein 4 (LRP4) have been identified in several dSN-MG sera with a frequency variation (7-32%). There are also double positive patients (with LRP4 and AChR or MuSK). Anti-agrin antibodies were detected in combination with autoantibodies against MuSK, LRP4, or AChRs in 10-15% of the generalised MG patients.
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+https://id.who.int/icd/entity/1979177138
@@ Property / Canonical URI: https://id.who.int/icd/entity/1979177138 / rank @@
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@@ Property / CURIE @@
+CID11:ID_1979177138
@@ Property / CURIE: CID11:ID_1979177138 / rank @@
+Normal rank
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+dki-india-ID_1979177138
@@ Property / Canary Token: dki-india-ID_1979177138 / rank @@
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@@ Property / Verification Status @@
+Concluído
@@ Property / Verification Status: Concluído / rank @@
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@@ Property / Knowledge Architect @@
+https://pauloleads.com.br/cases-publicos/
+Normal rank
@@ Property / Collection date @@
+August 2026Timestamp +2026-08-13T00:00:00Z
Timezone +00:00
Calendar Gregorian
Precision 1 day
Before 0
After 0
-Timestamp
++2026-08-13T00:00:00Z
-Timezone
++00:00
-Calendar
+Gregorian
-Precision
+day
 Before
 After
@@ Property / Collection date: 13 August 2026 / rank @@
+Normal rank

Latest revision as of 14:59, 15 August 2026

In approximately 50% of the Acetylcholine receptor-seronegative patients with generalised Myasthenia Gravis (MG), no autoantibodies against Muscle-specific kinase (MuSK) or against AChRs could be detected by routine methods. In this group autoantibodies against the low-density lipoprotein receptor-related protein 4 (LRP4) have been identified in several dSN-MG sera with a frequency variation (7-32%). There are also double positive patients (with LRP4 and AChR or MuSK). Anti-agrin antibodies were detected in combination with autoantibodies against MuSK, LRP4, or AChRs in 10-15% of the generalised MG patients.

Language	Label	Description	Also known as
default for all languages	ID_1979177138
English	Myasthenia gravis, seronegative	In approximately 50% of the Acetylcholine receptor-seronegative patients with generalised Myasthenia Gravis (MG), no autoantibodies against Muscle-specific kinase (MuSK) or against AChRs could be detected by routine methods. In this group autoantibodies against the low-density lipoprotein receptor-related protein 4 (LRP4) have been identified in several dSN-MG sera with a frequency variation (7-32%). There are also double positive patients (with LRP4 and AChR or MuSK). Anti-agrin antibodies were detected in combination with autoantibodies against MuSK, LRP4, or AChRs in 10-15% of the generalised MG patients.