Sporadic inclusion body myopathy (Q88128): Difference between revisions

Sporadic inclusion body myositis is the most frequent acquired myopathy of middle and later life and is distinguished from other inflammatory myopathies by its selective pattern of muscle involvement and slowly progressive course, and by the combination of inflammatory and degenerative muscle pathology and multi-protein deposits in muscle tissue. Typical disease phenotype includes slowly progressive weakness and wasting of the quadriceps and forearm muscles. A smaller group of patients present initially because of weakness of the long finger flexor muscles or bulbar weakness, with lower limb weakness occurring at a later stage.