https://determinar.ia.br/w/index.php?action=history&feed=atom&title=Item%3AQ88895 2026-10-22T11:20:54Z Revision history for this page on the wiki MediaWiki 1.45.4 https://determinar.ia.br/w/index.php?title=Item:Q88895&diff=489935&oldid=prev 2026-08-15T15:17:21Z

<p>‎<span dir="auto"><span class="autocomment">Changed an Item</span></span></p> <table style="background-color: #fff; color: #202122;" data-mw="interface"> <col class="diff-marker" /> <col class="diff-content" /> <col class="diff-marker" /> <col class="diff-content" /> <tr class="diff-title" lang="en"> <td colspan="2" style="background-color: #fff; color: #202122; text-align: center;">← Older revision</td> <td colspan="2" style="background-color: #fff; color: #202122; text-align: center;">Revision as of 15:17, 15 August 2026</td> </tr><tr><td colspan="2" class="diff-lineno"></td><td colspan="2" class="diff-lineno">Property / <a title="Property:P78" href="/wiki/Property:P78">Knowledge Architect</a></td></tr><tr><td colspan="2"> </td><td class="diff-marker" data-marker="+"></td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div><ins style="font-weight: bold; text-decoration: none;"><span><a rel="nofollow" class="external free" href="https://pauloleads.com.br/cases-publicos/">https://pauloleads.com.br/cases-publicos/</a></span></ins></div></td></tr><tr><td colspan="2" class="diff-lineno"></td><td colspan="2" class="diff-lineno">Property / <a title="Property:P78" href="/wiki/Property:P78">Knowledge Architect</a>: <a rel="nofollow" class="external free" href="https://pauloleads.com.br/cases-publicos/">https://pauloleads.com.br/cases-publicos/</a> / rank</td></tr><tr><td colspan="2"> </td><td class="diff-marker" data-marker="+"></td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div><ins style="font-weight: bold; text-decoration: none;"><span>Normal rank</span></ins></div></td></tr></table>

Determinaradmin https://determinar.ia.br/w/index.php?title=Item:Q88895&diff=489936&oldid=prev 2026-08-15T15:17:21Z

<p>‎<span dir="auto"><span class="autocomment">Changed an Item</span></span></p> <table style="background-color: #fff; color: #202122;" data-mw="interface"> <col class="diff-marker" /> <col class="diff-content" /> <col class="diff-marker" /> <col class="diff-content" /> <tr class="diff-title" lang="en"> <td colspan="2" style="background-color: #fff; color: #202122; text-align: center;">← Older revision</td> <td colspan="2" style="background-color: #fff; color: #202122; text-align: center;">Revision as of 15:17, 15 August 2026</td> </tr><tr><td colspan="2" class="diff-lineno"></td><td colspan="2" class="diff-lineno">Property / <a title="Property:P80" href="/wiki/Property:P80">Collection date</a></td></tr><tr><td colspan="2"> </td><td class="diff-marker" data-marker="+"></td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div><ins style="font-weight: bold; text-decoration: none;"><span><b class="wb-details wb-time-details wb-time-rendered">13 August 2026</b><table class="wb-details wb-time-details"><tr><th class="wb-time-isotime">Timestamp</th><td class="wb-time-isotime">+2026-08-13T00:00:00Z</td></tr><tr><th class="wb-time-timezone">Timezone</th><td class="wb-time-timezone">+00:00</td></tr><tr><th class="wb-time-calendar">Calendar</th><td class="wb-time-calendar">Gregorian</td></tr><tr><th class="wb-time-precision">Precision</th><td class="wb-time-precision">1 day</td></tr><tr><th class="wb-time-before">Before</th><td class="wb-time-before">0</td></tr><tr><th class="wb-time-after">After</th><td class="wb-time-after">0</td></tr></table></span></ins></div></td></tr><tr><td colspan="2" class="diff-lineno"></td><td colspan="2" class="diff-lineno">Property / <a title="Property:P80" href="/wiki/Property:P80">Collection date</a>: 13 August 2026 / rank</td></tr><tr><td colspan="2"> </td><td class="diff-marker" data-marker="+"></td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div><ins style="font-weight: bold; text-decoration: none;"><span>Normal rank</span></ins></div></td></tr> <!-- diff cache key my_wiki:diff:1.41:old-489935:rev-489936:lang-en --> </table>

Determinaradmin https://determinar.ia.br/w/index.php?title=Item:Q88895&diff=489932&oldid=prev 2026-08-15T15:17:20Z

<p>‎<span dir="auto"><span class="autocomment">Changed an Item</span></span></p> <table style="background-color: #fff; color: #202122;" data-mw="interface"> <col class="diff-marker" /> <col class="diff-content" /> <col class="diff-marker" /> <col class="diff-content" /> <tr class="diff-title" lang="en"> <td colspan="2" style="background-color: #fff; color: #202122; text-align: center;">← Older revision</td> <td colspan="2" style="background-color: #fff; color: #202122; text-align: center;">Revision as of 15:17, 15 August 2026</td> </tr><tr><td colspan="2" class="diff-lineno"></td><td colspan="2" class="diff-lineno">Property / <a title="Property:P67" href="/wiki/Property:P67">CURIE</a></td></tr><tr><td colspan="2"> </td><td class="diff-marker" data-marker="+"></td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div><ins style="font-weight: bold; text-decoration: none;"><span>CID11:ID_1718367094</span></ins></div></td></tr><tr><td colspan="2" class="diff-lineno"></td><td colspan="2" class="diff-lineno">Property / <a title="Property:P67" href="/wiki/Property:P67">CURIE</a>: CID11:ID_1718367094 / rank</td></tr><tr><td colspan="2"> </td><td class="diff-marker" data-marker="+"></td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div><ins style="font-weight: bold; text-decoration: none;"><span>Normal rank</span></ins></div></td></tr> <!-- diff cache key my_wiki:diff:1.41:old-489931:rev-489932:lang-en --> </table>

Determinaradmin https://determinar.ia.br/w/index.php?title=Item:Q88895&diff=489933&oldid=prev 2026-08-15T15:17:20Z

<p>‎<span dir="auto"><span class="autocomment">Changed an Item</span></span></p> <table style="background-color: #fff; color: #202122;" data-mw="interface"> <col class="diff-marker" /> <col class="diff-content" /> <col class="diff-marker" /> <col class="diff-content" /> <tr class="diff-title" lang="en"> <td colspan="2" style="background-color: #fff; color: #202122; text-align: center;">← Older revision</td> <td colspan="2" style="background-color: #fff; color: #202122; text-align: center;">Revision as of 15:17, 15 August 2026</td> </tr><tr><td colspan="2" class="diff-lineno"></td><td colspan="2" class="diff-lineno">Property / <a title="Property:P70" href="/wiki/Property:P70">Canary Token</a></td></tr><tr><td colspan="2"> </td><td class="diff-marker" data-marker="+"></td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div><ins style="font-weight: bold; text-decoration: none;"><span>dki-india-ID_1718367094</span></ins></div></td></tr><tr><td colspan="2" class="diff-lineno"></td><td colspan="2" class="diff-lineno">Property / <a title="Property:P70" href="/wiki/Property:P70">Canary Token</a>: dki-india-ID_1718367094 / rank</td></tr><tr><td colspan="2"> </td><td class="diff-marker" data-marker="+"></td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div><ins style="font-weight: bold; text-decoration: none;"><span>Normal rank</span></ins></div></td></tr></table>

Determinaradmin https://determinar.ia.br/w/index.php?title=Item:Q88895&diff=489934&oldid=prev 2026-08-15T15:17:20Z

<p>‎<span dir="auto"><span class="autocomment">Changed an Item</span></span></p> <table style="background-color: #fff; color: #202122;" data-mw="interface"> <col class="diff-marker" /> <col class="diff-content" /> <col class="diff-marker" /> <col class="diff-content" /> <tr class="diff-title" lang="en"> <td colspan="2" style="background-color: #fff; color: #202122; text-align: center;">← Older revision</td> <td colspan="2" style="background-color: #fff; color: #202122; text-align: center;">Revision as of 15:17, 15 August 2026</td> </tr><tr><td colspan="2" class="diff-lineno"></td><td colspan="2" class="diff-lineno">Property / <a title="Property:P86" href="/wiki/Property:P86">Verification Status</a></td></tr><tr><td colspan="2"> </td><td class="diff-marker" data-marker="+"></td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div><ins style="font-weight: bold; text-decoration: none;"><span>Concluído</span></ins></div></td></tr><tr><td colspan="2" class="diff-lineno"></td><td colspan="2" class="diff-lineno">Property / <a title="Property:P86" href="/wiki/Property:P86">Verification Status</a>: Concluído / rank</td></tr><tr><td colspan="2"> </td><td class="diff-marker" data-marker="+"></td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div><ins style="font-weight: bold; text-decoration: none;"><span>Normal rank</span></ins></div></td></tr></table>

Determinaradmin https://determinar.ia.br/w/index.php?title=Item:Q88895&diff=489930&oldid=prev 2026-08-15T15:17:19Z

<p>‎<span dir="auto"><span class="autocomment">Changed label, description and/or aliases in pt-br, en</span></span></p> <table style="background-color: #fff; color: #202122;" data-mw="interface"> <col class="diff-marker" /> <col class="diff-content" /> <col class="diff-marker" /> <col class="diff-content" /> <tr class="diff-title" lang="en"> <td colspan="2" style="background-color: #fff; color: #202122; text-align: center;">← Older revision</td> <td colspan="2" style="background-color: #fff; color: #202122; text-align: center;">Revision as of 15:17, 15 August 2026</td> </tr><tr><td colspan="2" class="diff-lineno">description / pt-br</td><td colspan="2" class="diff-lineno">description / pt-br</td></tr><tr><td colspan="2"> </td><td class="diff-marker" data-marker="+"></td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div><ins style="font-weight: bold; text-decoration: none;">A deficiência de Zap-70 (proteína associada à cadeia zeta de 70 kD) é uma forma autossômica recessiva de imunodeficiência combinada grave (SCID) caracterizada pela falta de células T CD8+ e presença normal de células T CD4+ circulantes. A doença é extremamente rara, com apenas 12 pacientes de 8 famílias não relacionadas relatados até agora. Quase todos os pacientes com defeitos de Zap-70 apresentaram características clínicas típicas de SCID no início da vida: infecção pulmonar grave frequentemente por patógenos oportunistas (Pneumocystis carinii), diarreia crônica, déficit de crescimento e candidíase persistente. A deficiência de Zap-70 é fatal, a menos que os pacientes sejam submetidos a transplante de medula óssea (TMO). No futuro, a terapia genética pode parecer uma forma alternativa de tratamento. A maioria dos defeitos do gene ZAP-70 identificados em humanos impedem a expressão de proteínas e estão concentrados em uma região crítica para estabilidade e atividade enzimática. As mutações incluem inserções, deleções e substituições de um único nucleotídeo. O diagnóstico pré-natal por análise do DNA das vilosidades coriônicas pode ser realizado.</ins></div></td></tr><tr><td colspan="2" class="diff-lineno">description / en</td><td colspan="2" class="diff-lineno">description / en</td></tr><tr><td colspan="2"> </td><td class="diff-marker" data-marker="+"></td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div><ins style="font-weight: bold; text-decoration: none;">Zap-70 (zeta-chain-associated protein 70 kD) deficiency is an autosomal recessive form of severe combined immune deficiency (SCID) that is characterised by lack of CD8+ T cells and normal presence of circulating CD4+ T cells. The disease is extremely rare, with only 12 patients from 8 unrelated families reported so far. Nearly all patients with Zap-70 defects presented with typical clinical features of SCID in early life: severe pulmonary infection often sustained by opportunistic pathogens (Pneumocystis carinii), chronic diarrhoea, failure to thrive, and persistent candidiasis. Zap-70 deficiency is ultimately fatal unless patients undergo bone marrow transplantation (BMT). In the future, gene therapy could appear to be an alternative form of treatment. Most of the ZAP-70 gene defects identified in humans prevent protein expression and are concentrated in a region that is critical for stability and enzymatic activity. Mutations include insertions, deletions, and substitutions of a single nucleotide. Antenatal diagnosis by analysis of chorionic villi DNA can be carried out.</ins></div></td></tr></table>

Determinaradmin https://determinar.ia.br/w/index.php?title=Item:Q88895&diff=489931&oldid=prev 2026-08-15T15:17:19Z

<p>‎<span dir="auto"><span class="autocomment">Changed an Item</span></span></p> <table style="background-color: #fff; color: #202122;" data-mw="interface"> <col class="diff-marker" /> <col class="diff-content" /> <col class="diff-marker" /> <col class="diff-content" /> <tr class="diff-title" lang="en"> <td colspan="2" style="background-color: #fff; color: #202122; text-align: center;">← Older revision</td> <td colspan="2" style="background-color: #fff; color: #202122; text-align: center;">Revision as of 15:17, 15 August 2026</td> </tr><tr><td colspan="2" class="diff-lineno"></td><td colspan="2" class="diff-lineno">Property / <a title="Property:P68" href="/wiki/Property:P68">Canonical URI</a></td></tr><tr><td colspan="2"> </td><td class="diff-marker" data-marker="+"></td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div><ins style="font-weight: bold; text-decoration: none;"><span><a rel="nofollow" class="external free" href="https://id.who.int/icd/entity/1718367094">https://id.who.int/icd/entity/1718367094</a></span></ins></div></td></tr><tr><td colspan="2" class="diff-lineno"></td><td colspan="2" class="diff-lineno">Property / <a title="Property:P68" href="/wiki/Property:P68">Canonical URI</a>: <a rel="nofollow" class="external free" href="https://id.who.int/icd/entity/1718367094">https://id.who.int/icd/entity/1718367094</a> / rank</td></tr><tr><td colspan="2"> </td><td class="diff-marker" data-marker="+"></td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div><ins style="font-weight: bold; text-decoration: none;"><span>Normal rank</span></ins></div></td></tr> <!-- diff cache key my_wiki:diff:1.41:old-489930:rev-489931:lang-en --> </table>

Determinaradmin https://determinar.ia.br/w/index.php?title=Item:Q88895&diff=489929&oldid=prev 2026-08-15T15:17:18Z

<p>‎<span dir="auto"><span class="autocomment">Created a new Item</span></span></p> <a href="https://determinar.ia.br/w/index.php?title=Item:Q88895&amp;diff=489929">Show changes</a>

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