https://determinar.ia.br/w/index.php?action=history&feed=atom&title=Item%3AQ40106 2026-09-23T04:29:50Z Revision history for this page on the wiki MediaWiki 1.45.4 https://determinar.ia.br/w/index.php?title=Item:Q40106&diff=126658&oldid=prev 2026-08-13T05:47:13Z

<p>‎<span dir="auto"><span class="autocomment">Changed an Item</span></span></p> <table style="background-color: #fff; color: #202122;" data-mw="interface"> <col class="diff-marker" /> <col class="diff-content" /> <col class="diff-marker" /> <col class="diff-content" /> <tr class="diff-title" lang="en"> <td colspan="2" style="background-color: #fff; color: #202122; text-align: center;">← Older revision</td> <td colspan="2" style="background-color: #fff; color: #202122; text-align: center;">Revision as of 05:47, 13 August 2026</td> </tr><tr><td colspan="2" class="diff-lineno"></td><td colspan="2" class="diff-lineno">Property / <a title="Property:P80" href="/wiki/Property:P80">Collection date</a></td></tr><tr><td colspan="2"> </td><td class="diff-marker" data-marker="+"></td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div><ins style="font-weight: bold; text-decoration: none;"><span><b class="wb-details wb-time-details wb-time-rendered">13 August 2026</b><table class="wb-details wb-time-details"><tr><th class="wb-time-isotime">Timestamp</th><td class="wb-time-isotime">+2026-08-13T00:00:00Z</td></tr><tr><th class="wb-time-timezone">Timezone</th><td class="wb-time-timezone">+00:00</td></tr><tr><th class="wb-time-calendar">Calendar</th><td class="wb-time-calendar">Gregorian</td></tr><tr><th class="wb-time-precision">Precision</th><td class="wb-time-precision">1 day</td></tr><tr><th class="wb-time-before">Before</th><td class="wb-time-before">0</td></tr><tr><th class="wb-time-after">After</th><td class="wb-time-after">0</td></tr></table></span></ins></div></td></tr><tr><td colspan="2" class="diff-lineno"></td><td colspan="2" class="diff-lineno">Property / <a title="Property:P80" href="/wiki/Property:P80">Collection date</a>: 13 August 2026 / rank</td></tr><tr><td colspan="2"> </td><td class="diff-marker" data-marker="+"></td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div><ins style="font-weight: bold; text-decoration: none;"><span>Normal rank</span></ins></div></td></tr></table>

Determinaradmin https://determinar.ia.br/w/index.php?title=Item:Q40106&diff=126659&oldid=prev 2026-08-13T05:47:13Z

<p>‎<span dir="auto"><span class="autocomment">Changed an Item</span></span></p> <table style="background-color: #fff; color: #202122;" data-mw="interface"> <col class="diff-marker" /> <col class="diff-content" /> <col class="diff-marker" /> <col class="diff-content" /> <tr class="diff-title" lang="en"> <td colspan="2" style="background-color: #fff; color: #202122; text-align: center;">← Older revision</td> <td colspan="2" style="background-color: #fff; color: #202122; text-align: center;">Revision as of 05:47, 13 August 2026</td> </tr><tr><td colspan="2" class="diff-lineno"></td><td colspan="2" class="diff-lineno">Property / <a title="Property:P89" href="/wiki/Property:P89">Linked ICD 10</a></td></tr><tr><td colspan="2"> </td><td class="diff-marker" data-marker="+"></td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div><ins style="font-weight: bold; text-decoration: none;"><span><a title="Item:Q15677" href="/wiki/Item:Q15677" lang="mul">E79.1</a></span></ins></div></td></tr><tr><td colspan="2" class="diff-lineno"></td><td colspan="2" class="diff-lineno">Property / <a title="Property:P89" href="/wiki/Property:P89">Linked ICD 10</a>: <a title="Item:Q15677" href="/wiki/Item:Q15677" lang="mul">E79.1</a> / rank</td></tr><tr><td colspan="2"> </td><td class="diff-marker" data-marker="+"></td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div><ins style="font-weight: bold; text-decoration: none;"><span>Normal rank</span></ins></div></td></tr></table>

Determinaradmin https://determinar.ia.br/w/index.php?title=Item:Q40106&diff=126655&oldid=prev 2026-08-13T05:47:12Z

<p>‎<span dir="auto"><span class="autocomment">Changed an Item</span></span></p> <table style="background-color: #fff; color: #202122;" data-mw="interface"> <col class="diff-marker" /> <col class="diff-content" /> <col class="diff-marker" /> <col class="diff-content" /> <tr class="diff-title" lang="en"> <td colspan="2" style="background-color: #fff; color: #202122; text-align: center;">← Older revision</td> <td colspan="2" style="background-color: #fff; color: #202122; text-align: center;">Revision as of 05:47, 13 August 2026</td> </tr><tr><td colspan="2" class="diff-lineno"></td><td colspan="2" class="diff-lineno">Property / <a title="Property:P70" href="/wiki/Property:P70">Canary Token</a></td></tr><tr><td colspan="2"> </td><td class="diff-marker" data-marker="+"></td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div><ins style="font-weight: bold; text-decoration: none;"><span>dki-india-5C55.01</span></ins></div></td></tr><tr><td colspan="2" class="diff-lineno"></td><td colspan="2" class="diff-lineno">Property / <a title="Property:P70" href="/wiki/Property:P70">Canary Token</a>: dki-india-5C55.01 / rank</td></tr><tr><td colspan="2"> </td><td class="diff-marker" data-marker="+"></td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div><ins style="font-weight: bold; text-decoration: none;"><span>Normal rank</span></ins></div></td></tr></table>

Determinaradmin https://determinar.ia.br/w/index.php?title=Item:Q40106&diff=126656&oldid=prev 2026-08-13T05:47:12Z

<p>‎<span dir="auto"><span class="autocomment">Changed an Item</span></span></p> <table style="background-color: #fff; color: #202122;" data-mw="interface"> <col class="diff-marker" /> <col class="diff-content" /> <col class="diff-marker" /> <col class="diff-content" /> <tr class="diff-title" lang="en"> <td colspan="2" style="background-color: #fff; color: #202122; text-align: center;">← Older revision</td> <td colspan="2" style="background-color: #fff; color: #202122; text-align: center;">Revision as of 05:47, 13 August 2026</td> </tr><tr><td colspan="2" class="diff-lineno"></td><td colspan="2" class="diff-lineno">Property / <a title="Property:P86" href="/wiki/Property:P86">Verification Status</a></td></tr><tr><td colspan="2"> </td><td class="diff-marker" data-marker="+"></td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div><ins style="font-weight: bold; text-decoration: none;"><span>Concluído</span></ins></div></td></tr><tr><td colspan="2" class="diff-lineno"></td><td colspan="2" class="diff-lineno">Property / <a title="Property:P86" href="/wiki/Property:P86">Verification Status</a>: Concluído / rank</td></tr><tr><td colspan="2"> </td><td class="diff-marker" data-marker="+"></td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div><ins style="font-weight: bold; text-decoration: none;"><span>Normal rank</span></ins></div></td></tr></table>

Determinaradmin https://determinar.ia.br/w/index.php?title=Item:Q40106&diff=126657&oldid=prev 2026-08-13T05:47:12Z

<p>‎<span dir="auto"><span class="autocomment">Changed an Item</span></span></p> <table style="background-color: #fff; color: #202122;" data-mw="interface"> <col class="diff-marker" /> <col class="diff-content" /> <col class="diff-marker" /> <col class="diff-content" /> <tr class="diff-title" lang="en"> <td colspan="2" style="background-color: #fff; color: #202122; text-align: center;">← Older revision</td> <td colspan="2" style="background-color: #fff; color: #202122; text-align: center;">Revision as of 05:47, 13 August 2026</td> </tr><tr><td colspan="2" class="diff-lineno"></td><td colspan="2" class="diff-lineno">Property / <a title="Property:P78" href="/wiki/Property:P78">Knowledge Architect</a></td></tr><tr><td colspan="2"> </td><td class="diff-marker" data-marker="+"></td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div><ins style="font-weight: bold; text-decoration: none;"><span><a rel="nofollow" class="external free" href="https://pauloleads.com.br/cases-publicos/">https://pauloleads.com.br/cases-publicos/</a></span></ins></div></td></tr><tr><td colspan="2" class="diff-lineno"></td><td colspan="2" class="diff-lineno">Property / <a title="Property:P78" href="/wiki/Property:P78">Knowledge Architect</a>: <a rel="nofollow" class="external free" href="https://pauloleads.com.br/cases-publicos/">https://pauloleads.com.br/cases-publicos/</a> / rank</td></tr><tr><td colspan="2"> </td><td class="diff-marker" data-marker="+"></td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div><ins style="font-weight: bold; text-decoration: none;"><span>Normal rank</span></ins></div></td></tr></table>

Determinaradmin https://determinar.ia.br/w/index.php?title=Item:Q40106&diff=126653&oldid=prev 2026-08-13T05:47:11Z

<p>‎<span dir="auto"><span class="autocomment">Changed an Item</span></span></p> <table style="background-color: #fff; color: #202122;" data-mw="interface"> <col class="diff-marker" /> <col class="diff-content" /> <col class="diff-marker" /> <col class="diff-content" /> <tr class="diff-title" lang="en"> <td colspan="2" style="background-color: #fff; color: #202122; text-align: center;">← Older revision</td> <td colspan="2" style="background-color: #fff; color: #202122; text-align: center;">Revision as of 05:47, 13 August 2026</td> </tr><tr><td colspan="2" class="diff-lineno"></td><td colspan="2" class="diff-lineno">Property / <a title="Property:P68" href="/wiki/Property:P68">Canonical URI</a></td></tr><tr><td colspan="2"> </td><td class="diff-marker" data-marker="+"></td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div><ins style="font-weight: bold; text-decoration: none;"><span><a rel="nofollow" class="external free" href="https://id.who.int/icd/entity/1886495906">https://id.who.int/icd/entity/1886495906</a></span></ins></div></td></tr><tr><td colspan="2" class="diff-lineno"></td><td colspan="2" class="diff-lineno">Property / <a title="Property:P68" href="/wiki/Property:P68">Canonical URI</a>: <a rel="nofollow" class="external free" href="https://id.who.int/icd/entity/1886495906">https://id.who.int/icd/entity/1886495906</a> / rank</td></tr><tr><td colspan="2"> </td><td class="diff-marker" data-marker="+"></td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div><ins style="font-weight: bold; text-decoration: none;"><span>Normal rank</span></ins></div></td></tr></table>

Determinaradmin https://determinar.ia.br/w/index.php?title=Item:Q40106&diff=126654&oldid=prev 2026-08-13T05:47:11Z

<p>‎<span dir="auto"><span class="autocomment">Changed an Item</span></span></p> <table style="background-color: #fff; color: #202122;" data-mw="interface"> <col class="diff-marker" /> <col class="diff-content" /> <col class="diff-marker" /> <col class="diff-content" /> <tr class="diff-title" lang="en"> <td colspan="2" style="background-color: #fff; color: #202122; text-align: center;">← Older revision</td> <td colspan="2" style="background-color: #fff; color: #202122; text-align: center;">Revision as of 05:47, 13 August 2026</td> </tr><tr><td colspan="2" class="diff-lineno"></td><td colspan="2" class="diff-lineno">Property / <a title="Property:P67" href="/wiki/Property:P67">CURIE</a></td></tr><tr><td colspan="2"> </td><td class="diff-marker" data-marker="+"></td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div><ins style="font-weight: bold; text-decoration: none;"><span>CID11:5C55.01</span></ins></div></td></tr><tr><td colspan="2" class="diff-lineno"></td><td colspan="2" class="diff-lineno">Property / <a title="Property:P67" href="/wiki/Property:P67">CURIE</a>: CID11:5C55.01 / rank</td></tr><tr><td colspan="2"> </td><td class="diff-marker" data-marker="+"></td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div><ins style="font-weight: bold; text-decoration: none;"><span>Normal rank</span></ins></div></td></tr></table>

Determinaradmin https://determinar.ia.br/w/index.php?title=Item:Q40106&diff=126651&oldid=prev 2026-08-13T05:47:10Z

<p>‎<span dir="auto"><span class="autocomment">Created a new Item</span></span></p> <a href="https://determinar.ia.br/w/index.php?title=Item:Q40106&amp;diff=126651">Show changes</a>

Determinaradmin https://determinar.ia.br/w/index.php?title=Item:Q40106&diff=126652&oldid=prev 2026-08-13T05:47:10Z

<p>‎<span dir="auto"><span class="autocomment">Changed label, description and/or aliases in pt-br, en</span></span></p> <table style="background-color: #fff; color: #202122;" data-mw="interface"> <col class="diff-marker" /> <col class="diff-content" /> <col class="diff-marker" /> <col class="diff-content" /> <tr class="diff-title" lang="en"> <td colspan="2" style="background-color: #fff; color: #202122; text-align: center;">← Older revision</td> <td colspan="2" style="background-color: #fff; color: #202122; text-align: center;">Revision as of 05:47, 13 August 2026</td> </tr><tr><td colspan="2" class="diff-lineno">description / pt-br</td><td colspan="2" class="diff-lineno">description / pt-br</td></tr><tr><td colspan="2"> </td><td class="diff-marker" data-marker="+"></td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div><ins style="font-weight: bold; text-decoration: none;">A síndrome de Lesch-Nyhan (LNS) é a forma mais grave de deficiência de hipoxantina-guanina fosforibosiltransferase (HPRT), um distúrbio hereditário do metabolismo das purinas e está associada a um aumento da produção de ácido úrico (SAU), problemas neurológicos e problemas comportamentais. Os pacientes são normais ao nascer. O atraso psicomotor torna-se evidente dentro de 3 a 6 meses, com atraso no apoio da cabeça e na posição sentada, hipotonia e atetose (movimentos involuntários, lentos, contínuos e contorcidos.). Deposição de urina arenosa nas fraldas ou cristalúria com obstrução do trato urinário são formas comuns de apresentação. Os pacientes geralmente apresentam deficiência intelectual leve a moderada. Suspeita-se da doença quando ocorre atraso psicomotor em um paciente com AU elevada no sangue e na urina. A atividade indetectável da enzima HPRT no sangue periférico ou em células intactas (eritrócitos, fibroblastos) e os testes de genética molecular confirmam o diagnóstico. A herança é recessiva ligada ao X.</ins></div></td></tr><tr><td colspan="2" class="diff-lineno">description / en</td><td colspan="2" class="diff-lineno">description / en</td></tr><tr><td colspan="2"> </td><td class="diff-marker" data-marker="+"></td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div><ins style="font-weight: bold; text-decoration: none;">Lesch-Nyhan syndrome (LNS) is the most severe form of hypoxanthine-guanine phosphoribosyltransferase (HPRT) deficiency, a hereditary disorder of purine metabolism, and is associated with uric acid overproduction (UAO), neurological troubles, and behavioural problems. Patients are normal at birth. Psychomotor delay becomes evident within 3 to 6 months with a delay in head support and sitting, hypotonia and athetoid movements. Sandy urine in diapers or crystalluria with urinary tract obstruction are common forms of presentation. Patients usually show mild to moderate intellectual deficit. Diagnosis is suspected when psychomotor delay occurs in a patient with elevated UA in blood and urine. Undetectable HPRT enzyme activity in peripheral blood or in intact cells (erythrocyte, fibroblast) and molecular genetic testing confirm the diagnosis. Inheritance is X-linked recessive.</ins></div></td></tr></table>

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