{"entities":{"Q98488":{"pageid":88881,"ns":120,"title":"Item:Q98488","lastrevid":558931,"modified":"2026-08-16T14:59:57Z","type":"item","id":"Q98488","labels":{"mul":{"language":"mul","value":"ID_20200096"},"pt-br":{"language":"pt-br","value":"Heterotopia nodular periventricular"},"en":{"language":"en","value":"Periventricular nodular heterotopia"}},"descriptions":{"pt-br":{"language":"pt-br","value":"Heterotopia nodular periventricular (HNP) \u00e9 uma malforma\u00e7\u00e3o cerebral, devida \u00e0 migra\u00e7\u00e3o neuronal anormal, na qual um subconjunto de neur\u00f4nios n\u00e3o consegue migrar para o c\u00f3rtex cerebral em desenvolvimento e permanece como n\u00f3dulos que revestem a superf\u00edcie ventricular. A HPN cl\u00e1ssica \u00e9 um raro transtorno dominante ligado ao X, muito mais frequente em mulheres que apresentam intelig\u00eancia normal a d\u00e9ficit intelectual lim\u00edtrofe, epilepsia de gravidade vari\u00e1vel e sinais externos ao sistema nervoso, especialmente defeitos cardiovasculares ou coagulopatia. O transtorno geralmente est\u00e1 associado \u00e0 letalidade pr\u00e9-natal em homens."},"en":{"language":"en","value":"Periventricular nodular heterotopia (PNH) is a brain malformation, due to abnormal neuronal migration, in which a subset of neurons fails to migrate into the developing cerebral cortex and remains as nodules that line the ventricular surface. Classical PNH is a rare X-linked dominant disorder far more frequent in females who present normal intelligence to borderline intellectual deficit, epilepsy of variable severity and extra-central nervous system signs, especially cardiovascular defects or coagulopathy. The disorder is generally associated with prenatal lethality in males."}},"aliases":{},"claims":{"P68":[{"mainsnak":{"snaktype":"value","property":"P68","hash":"01129ee8ab6debe02151495461a9e5cfcf86503d","datavalue":{"value":"https://id.who.int/icd/entity/20200096","type":"string"},"datatype":"url"},"type":"statement","id":"Q98488$BFB58B6D-96FE-4BE5-B38C-38D64E104C38","rank":"normal"}],"P67":[{"mainsnak":{"snaktype":"value","property":"P67","hash":"8d61f8378e71f2f7f37e13bfa2feb6a84c2a940a","datavalue":{"value":"CID11:ID_20200096","type":"string"},"datatype":"string"},"type":"statement","id":"Q98488$5F3FF712-4816-4731-B418-DD7960262AED","rank":"normal"}],"P70":[{"mainsnak":{"snaktype":"value","property":"P70","hash":"9a2c614f35656bfc90d355c4bfb56d0e2f7af7c9","datavalue":{"value":"dki-india-ID_20200096","type":"string"},"datatype":"string"},"type":"statement","id":"Q98488$9620DACA-37C4-4739-8B47-65DF334AB903","rank":"normal"}],"P86":[{"mainsnak":{"snaktype":"value","property":"P86","hash":"a96031634b9f5dafddaf781bbba3adea6bb64ef4","datavalue":{"value":"Conclu\u00eddo","type":"string"},"datatype":"string"},"type":"statement","id":"Q98488$3E72F84C-785D-452B-B132-EA88AB7872BE","rank":"normal"}],"P78":[{"mainsnak":{"snaktype":"value","property":"P78","hash":"5f9b5be68b7400da549761cf15abfdbc4d1e075b","datavalue":{"value":"https://pauloleads.com.br/cases-publicos/","type":"string"},"datatype":"url"},"type":"statement","id":"Q98488$ED8DDA7F-A254-4D7D-91C7-A2651351B452","rank":"normal"}],"P80":[{"mainsnak":{"snaktype":"value","property":"P80","hash":"378ac503ed43f21e1f461d2823a6ad59da580514","datavalue":{"value":{"time":"+2026-08-15T00:00:00Z","timezone":0,"before":0,"after":0,"precision":11,"calendarmodel":"http://www.wikidata.org/entity/Q1985727"},"type":"time"},"datatype":"time"},"type":"statement","id":"Q98488$8D75FD29-501C-4D61-AF9D-FB75C93F815E","rank":"normal"}]},"sitelinks":{}}}}