{"entities":{"Q92750":{"pageid":83143,"ns":120,"title":"Item:Q92750","lastrevid":517417,"modified":"2026-08-16T07:52:45Z","type":"item","id":"Q92750","labels":{"mul":{"language":"mul","value":"ID_339968706"},"pt-br":{"language":"pt-br","value":"S\u00edndrome cong\u00eanita do canal lento"},"en":{"language":"en","value":"Congenital slow channel syndrome"}},"descriptions":{"pt-br":{"language":"pt-br","value":"Na s\u00edndrome do canal lento, um subtipo de s\u00edndrome miast\u00eanica cong\u00eanita com defeito p\u00f3s-sin\u00e1ptico, h\u00e1 um envolvimento grave e seletivo dos m\u00fasculos extensores cervicais, do punho e dos dedos na maioria dos casos. M\u00fasculos cranianos s\u00e3o ligeiramente afetados; curso lentamente progressivo. Piorado pela terapia com piridostigmina de longo prazo; pouca ou nenhuma resposta ao edrof\u00f4nio. Heran\u00e7a autoss\u00f4mica dominante em quase todos os casos._x000D_ _x000D_ A estimula\u00e7\u00e3o nervosa repetitiva mostra decremento e potenciais de a\u00e7\u00e3o muscular compostos repetitivos."},"en":{"language":"en","value":"In slow channel syndrome, a congenital myasthenic syndrome subtype with a postsynaptic defect, there is selectively severe involvement of cervical and wrist and finger extensor muscles in most cases. Cranial muscles only mildly affected; slowly progressive course. Worsened by long-term pyridostigmine therapy; little or no response to edrophonium. Dominant inheritance in nearly all cases. Repetitive nerve stimulation shows decrement and repetitive compound muscle action potentials."}},"aliases":{},"claims":{"P68":[{"mainsnak":{"snaktype":"value","property":"P68","hash":"52f108c80ade56b77513ed3041c23937fbe5f5ab","datavalue":{"value":"https://id.who.int/icd/entity/339968706","type":"string"},"datatype":"url"},"type":"statement","id":"Q92750$15806AB3-CDD0-400E-A249-8F55DD091F96","rank":"normal"}],"P67":[{"mainsnak":{"snaktype":"value","property":"P67","hash":"1d6e13cf8db3348d9b29d81f284f2501b5d9115a","datavalue":{"value":"CID11:ID_339968706","type":"string"},"datatype":"string"},"type":"statement","id":"Q92750$4B47C69D-3C94-4BBA-A9EB-955B4E59DDE7","rank":"normal"}],"P70":[{"mainsnak":{"snaktype":"value","property":"P70","hash":"db81f222b1dfbeea98495497aa898cd4319f02ef","datavalue":{"value":"dki-india-ID_339968706","type":"string"},"datatype":"string"},"type":"statement","id":"Q92750$741D6DDE-9FB5-4C70-95B7-794876DF6CCB","rank":"normal"}],"P86":[{"mainsnak":{"snaktype":"value","property":"P86","hash":"a96031634b9f5dafddaf781bbba3adea6bb64ef4","datavalue":{"value":"Conclu\u00eddo","type":"string"},"datatype":"string"},"type":"statement","id":"Q92750$C43E9FD1-749A-43C1-B906-80EFAC590D09","rank":"normal"}],"P78":[{"mainsnak":{"snaktype":"value","property":"P78","hash":"5f9b5be68b7400da549761cf15abfdbc4d1e075b","datavalue":{"value":"https://pauloleads.com.br/cases-publicos/","type":"string"},"datatype":"url"},"type":"statement","id":"Q92750$7B09735F-C00E-40D3-AF16-20E2309C019C","rank":"normal"}],"P80":[{"mainsnak":{"snaktype":"value","property":"P80","hash":"378ac503ed43f21e1f461d2823a6ad59da580514","datavalue":{"value":{"time":"+2026-08-15T00:00:00Z","timezone":0,"before":0,"after":0,"precision":11,"calendarmodel":"http://www.wikidata.org/entity/Q1985727"},"type":"time"},"datatype":"time"},"type":"statement","id":"Q92750$EB9B64CA-E605-4838-8FB6-A9BA864588DF","rank":"normal"}]},"sitelinks":{}}}}