{"entities":{"Q89412":{"pageid":79798,"ns":120,"title":"Item:Q89412","lastrevid":493701,"modified":"2026-08-15T16:06:14Z","type":"item","id":"Q89412","labels":{"mul":{"language":"mul","value":"ID_1145853843"},"pt-br":{"language":"pt-br","value":"Encefalopatia devida a hidroxiquinurenin\u00faria"},"en":{"language":"en","value":"Encephalopathy due to hydroxykynureninuria"}},"descriptions":{"pt-br":{"language":"pt-br","value":"A encefalopatia devida a hidroxiquinurenin\u00faria \u00e9 caracterizada por retardo psicomotor e encefalopatia n\u00e3o progressiva associada \u00e0 excre\u00e7\u00e3o urin\u00e1ria de grandes quantidades de quinurenina, 3-hidroxiquinurenina e \u00e1cido xantur\u00eanico. Foi descrito em menos de 30 pacientes. Outras manifesta\u00e7\u00f5es podem incluir hipertonia muscular, dores de cabe\u00e7a e gestos estereotipados. Esta doen\u00e7a \u00e9 transmitida de forma autoss\u00f4mica recessiva. \u00c9 causada por um defeito na quinureninase, uma enzima da via catab\u00f3lica do triptofano."},"en":{"language":"en","value":"Encephalopathy due to hydroxykynureninuria is characterised by psychomotor retardation and nonprogressive encephalopathy associated with urinary excretion of large amounts of kynurenine, 3-hydroxykynurenine, and xanthurenic acid. It has been described in less than 30 patients. Other manifestations may include muscular hypertonia, headaches and stereotyped gestures. This disorder is transmitted as an autosomal recessive trait. It is caused by a defect in kynureninase, an enzyme of the tryptophane catabolic pathway."}},"aliases":{},"claims":{"P68":[{"mainsnak":{"snaktype":"value","property":"P68","hash":"d6c7dca3f33ce6f6cfd7ece9231d0fb44150bc69","datavalue":{"value":"https://id.who.int/icd/entity/1145853843","type":"string"},"datatype":"url"},"type":"statement","id":"Q89412$6D0B598F-6370-4CD2-98F7-692EAD9B1A54","rank":"normal"}],"P67":[{"mainsnak":{"snaktype":"value","property":"P67","hash":"6781ed4b5b9f2ab6db5bec13248f641084cd45ab","datavalue":{"value":"CID11:ID_1145853843","type":"string"},"datatype":"string"},"type":"statement","id":"Q89412$66111D4C-3461-4620-A2CD-5517D1027422","rank":"normal"}],"P70":[{"mainsnak":{"snaktype":"value","property":"P70","hash":"804df18e4c7c1d9d794b126aea8e9506c5c81c5f","datavalue":{"value":"dki-india-ID_1145853843","type":"string"},"datatype":"string"},"type":"statement","id":"Q89412$78A65F81-4747-4625-9A94-1F82DCFC55C2","rank":"normal"}],"P86":[{"mainsnak":{"snaktype":"value","property":"P86","hash":"a96031634b9f5dafddaf781bbba3adea6bb64ef4","datavalue":{"value":"Conclu\u00eddo","type":"string"},"datatype":"string"},"type":"statement","id":"Q89412$DEEA8062-E2FB-4BC3-8C88-1205F5D6EB3D","rank":"normal"}],"P78":[{"mainsnak":{"snaktype":"value","property":"P78","hash":"5f9b5be68b7400da549761cf15abfdbc4d1e075b","datavalue":{"value":"https://pauloleads.com.br/cases-publicos/","type":"string"},"datatype":"url"},"type":"statement","id":"Q89412$F1F8A014-C3A2-4802-AE30-6EE141DEFB36","rank":"normal"}],"P80":[{"mainsnak":{"snaktype":"value","property":"P80","hash":"92b8222fcbb75718504f915073a3f43bd4003d18","datavalue":{"value":{"time":"+2026-08-13T00:00:00Z","timezone":0,"before":0,"after":0,"precision":11,"calendarmodel":"http://www.wikidata.org/entity/Q1985727"},"type":"time"},"datatype":"time"},"type":"statement","id":"Q89412$0CF0C584-4ABC-4838-B12A-6F5B67DF93F5","rank":"normal"}]},"sitelinks":{}}}}