{"entities":{"Q88643":{"pageid":79028,"ns":120,"title":"Item:Q88643","lastrevid":488066,"modified":"2026-08-15T14:57:40Z","type":"item","id":"Q88643","labels":{"mul":{"language":"mul","value":"ID_422441512"},"pt-br":{"language":"pt-br","value":"Miastenia gravis, anticorpo MuSK positivo"},"en":{"language":"en","value":"Myasthenia gravis, MuSK antibody positive"}},"descriptions":{"pt-br":{"language":"pt-br","value":"Aproximadamente 50% dos pacientes sem autoanticorpos contra o receptor de acetilcolina possuem autoanticorpos contra a quinase muscular espec\u00edfica (MuSK). MG anti-MusK positivo \u00e9 uma entidade de doen\u00e7a separada devido ao padr\u00e3o caracter\u00edstico de fraqueza, curso da doen\u00e7a e fisiopatologia. MG anti-MusK positivo \u00e9 20 vezes mais rara que MG anti-AChR positivo (preval\u00eancia de 1\u20132 por 10.000 pessoas). A maioria dos pacientes \u00e9 do sexo feminino, tem in\u00edcio <40 anos, apresenta ptose e diplopia, pode desenvolver rapidamente fraqueza bulbar (apresenta\u00e7\u00e3o oculobulbar) e apresenta maior risco de crise respirat\u00f3ria. Um ter\u00e7o a metade dos pacientes com MG anti-MuSK positivo podem apresentar crises miast\u00eanicas que requerem suporte ventilat\u00f3rio. A fraqueza dos m\u00fasculos dos membros \u00e9 menos grave. Pequenos timomas foram ocasionalmente relatados."},"en":{"language":"en","value":"Approximately 50% of the Acetylcholine receptor-negative patients have autoantibodies against muscle-specific kinase (MuSK). MuSK MG is a separate disease entity given the characteristic pattern of weakness, disease course and pathophysiology. MuSK MG is 20 x as rare as AChR \u2013positive MG (prevalence 1\u20132 per 10,000 persons). Most patients are female, have an onset <40 years, present with ptosis and diplopia, may rapidly develop bulbar weakness (oculobulbar presentation) and are at higher risk of respiratory crisis. One-third to half of MuSK MG patients may experience myasthenic crises requiring ventilatory support. Limb muscle weakness is less severe. Small thymomas have occasionally been reported."}},"aliases":{},"claims":{"P68":[{"mainsnak":{"snaktype":"value","property":"P68","hash":"56bc14620f6d521ba41a18b122c94286ea0fa544","datavalue":{"value":"https://id.who.int/icd/entity/422441512","type":"string"},"datatype":"url"},"type":"statement","id":"Q88643$B899A06D-FEF2-4B75-A400-390F8FCD2CA9","rank":"normal"}],"P67":[{"mainsnak":{"snaktype":"value","property":"P67","hash":"e649883717ae528b9f040dee1802f3fa2ce218b7","datavalue":{"value":"CID11:ID_422441512","type":"string"},"datatype":"string"},"type":"statement","id":"Q88643$7243E9E0-A3A9-4DE1-AF4C-D2031EBF0F26","rank":"normal"}],"P70":[{"mainsnak":{"snaktype":"value","property":"P70","hash":"78add109e33c2c18c9d8326816fddb0e22121bcc","datavalue":{"value":"dki-india-ID_422441512","type":"string"},"datatype":"string"},"type":"statement","id":"Q88643$2E6B5D1F-36CE-4053-BEB0-9694261A681F","rank":"normal"}],"P86":[{"mainsnak":{"snaktype":"value","property":"P86","hash":"a96031634b9f5dafddaf781bbba3adea6bb64ef4","datavalue":{"value":"Conclu\u00eddo","type":"string"},"datatype":"string"},"type":"statement","id":"Q88643$E8EDAD89-BD52-41AD-9145-9A029CDE05E3","rank":"normal"}],"P78":[{"mainsnak":{"snaktype":"value","property":"P78","hash":"5f9b5be68b7400da549761cf15abfdbc4d1e075b","datavalue":{"value":"https://pauloleads.com.br/cases-publicos/","type":"string"},"datatype":"url"},"type":"statement","id":"Q88643$14EF2F95-2730-460B-AF2F-595501FED543","rank":"normal"}],"P80":[{"mainsnak":{"snaktype":"value","property":"P80","hash":"92b8222fcbb75718504f915073a3f43bd4003d18","datavalue":{"value":{"time":"+2026-08-13T00:00:00Z","timezone":0,"before":0,"after":0,"precision":11,"calendarmodel":"http://www.wikidata.org/entity/Q1985727"},"type":"time"},"datatype":"time"},"type":"statement","id":"Q88643$AE71B64C-44F5-4803-8E2E-3411AFBB1B52","rank":"normal"}]},"sitelinks":{}}}}