{"entities":{"Q85868":{"pageid":76253,"ns":120,"title":"Item:Q85868","lastrevid":467889,"modified":"2026-08-15T11:13:43Z","type":"item","id":"Q85868","labels":{"mul":{"language":"mul","value":"ID_1269266075"},"pt-br":{"language":"pt-br","value":"S\u00edndrome do QT longo tipo 1"},"en":{"language":"en","value":"Long QT syndrome type 1"}},"descriptions":{"pt-br":{"language":"pt-br","value":"LQT1 \u00e9 o tipo mais comum de s\u00edndrome do QT longo, representando cerca de 30 a 35 por cento de todos os casos. O gene LQT1 \u00e9 o KCNQ1, que foi isolado no cromossomo 11p15.5. KCNQ1 codifica o canal de pot\u00e1ssio controlado por voltagem KvLQT1 que \u00e9 altamente expresso no cora\u00e7\u00e3o. Acredita-se que o produto do gene KCNQ1 produza uma subunidade alfa que interage com outras prote\u00ednas (em particular, a subunidade beta minK) para criar o canal i\u00f4nico IKs, que \u00e9 respons\u00e1vel pela corrente retificadora de pot\u00e1ssio atrasada do potencial de a\u00e7\u00e3o card\u00edaco."},"en":{"language":"en","value":"LQT1 is the most common type of long QT syndrome, making up about 30 to 35 percent of all cases. The LQT1 gene is KCNQ1, which has been isolated to chromosome 11p15.5. KCNQ1 codes for the voltage-gated potassium channel KvLQT1 that is highly expressed in the heart. It is believed that the product of the KCNQ1 gene produces an alpha subunit that interacts with other proteins (in particular, the minK beta subunit) to create the IKs ion channel, which is responsible for the delayed potassium rectifier current of the cardiac action potential."}},"aliases":{},"claims":{"P68":[{"mainsnak":{"snaktype":"value","property":"P68","hash":"4519fc3fa6af719977f3b3c5e6b331fb77f0ff24","datavalue":{"value":"https://id.who.int/icd/entity/1269266075","type":"string"},"datatype":"url"},"type":"statement","id":"Q85868$D7A27228-6A32-42B7-94A1-8B6C0BB2B67B","rank":"normal"}],"P67":[{"mainsnak":{"snaktype":"value","property":"P67","hash":"393e30403f2ea0e0553cddfc96a32d3d70210711","datavalue":{"value":"CID11:ID_1269266075","type":"string"},"datatype":"string"},"type":"statement","id":"Q85868$C5779697-B440-42D7-8C3E-CF3DD183195A","rank":"normal"}],"P70":[{"mainsnak":{"snaktype":"value","property":"P70","hash":"f55266dc892e22bdeafead632e6d29c4a4e9a5be","datavalue":{"value":"dki-india-ID_1269266075","type":"string"},"datatype":"string"},"type":"statement","id":"Q85868$3FC20261-4E27-4F30-8875-44647A653E7E","rank":"normal"}],"P86":[{"mainsnak":{"snaktype":"value","property":"P86","hash":"a96031634b9f5dafddaf781bbba3adea6bb64ef4","datavalue":{"value":"Conclu\u00eddo","type":"string"},"datatype":"string"},"type":"statement","id":"Q85868$7DF0A55C-A93A-431F-8D03-EBF309E06798","rank":"normal"}],"P78":[{"mainsnak":{"snaktype":"value","property":"P78","hash":"5f9b5be68b7400da549761cf15abfdbc4d1e075b","datavalue":{"value":"https://pauloleads.com.br/cases-publicos/","type":"string"},"datatype":"url"},"type":"statement","id":"Q85868$510C10EB-1C43-43F0-B56A-1AB3E6685B42","rank":"normal"}],"P80":[{"mainsnak":{"snaktype":"value","property":"P80","hash":"92b8222fcbb75718504f915073a3f43bd4003d18","datavalue":{"value":{"time":"+2026-08-13T00:00:00Z","timezone":0,"before":0,"after":0,"precision":11,"calendarmodel":"http://www.wikidata.org/entity/Q1985727"},"type":"time"},"datatype":"time"},"type":"statement","id":"Q85868$EF76C36D-2DFD-4A72-A2A5-E7380B02CC19","rank":"normal"}]},"sitelinks":{}}}}