{"entities":{"Q85585":{"pageid":75970,"ns":120,"title":"Item:Q85585","lastrevid":465836,"modified":"2026-08-15T10:56:50Z","type":"item","id":"Q85585","labels":{"mul":{"language":"mul","value":"ID_1363394816"},"pt-br":{"language":"pt-br","value":"Doen\u00e7a de Creutzfeldt-Jakob tal\u00e2mica espor\u00e1dica"},"en":{"language":"en","value":"Thalamic sporadic Creutzfeldt-Jakob Disease"}},"descriptions":{"pt-br":{"language":"pt-br","value":"Um dos poucos subtipos de DCJe, Creutzfeldt-Jakob tal\u00e2mica espor\u00e1dica (DCJe) \u00e9 caracterizado pelo envolvimento grave do t\u00e1lamo e do n\u00facleo olivar inferior com caracter\u00edsticas cl\u00ednicas de comprometimento auton\u00f4mico predominante, como ins\u00f4nia, na ins\u00f4nia familiar fatal (FFI). A imagem por resson\u00e2ncia magn\u00e9tica (imagem ponderada por difus\u00e3o), l\u00edquido cefalorraquidiano e eletroencefalograma n\u00e3o mostram caracter\u00edsticas caracter\u00edsticas. A tomografia computadorizada por emiss\u00e3o de f\u00f3ton \u00fanico (SPECT) e a tomografia por emiss\u00e3o de p\u00f3sitrons (PET) revelam hipometabolismo do t\u00e1lamo. A prote\u00edna pri\u00f4nica acumulada \u00e9 MM2 (MM2-tal\u00e2mica), o que significa que h\u00e1 uma prote\u00edna pri\u00f4nica anormal do tipo 2 com homozigoto de metionina no local polim\u00f3rfico do c\u00f3don 129 do gene da prote\u00edna pri\u00f4nica."},"en":{"language":"en","value":"One of the few sub-types of sCJD, Thalamic sporadic Creutzfeldt-Jakob (sCJD) is characterised by severe involvement of the thalamus and inferior olivary nucleus with clinical features of predominant autonomic impairment such as insomnia like fatal familial insomnia (FFI). Magnetic resonance imaging (diffusion weighted imaging), cerebrospinal fluid, and electroencephalogram do not show characteristic features. Single photon emission computed tomography (SPECT) and positron emission tomography (PET) reveals hypometabolism of the thalamus. The accumulated prion protein is MM2 (MM2-thalamic) which means there is a type 2 abnormal prion protein with methionine homozygote at codon 129 polymorphic site of prion protein gene."}},"aliases":{},"claims":{"P68":[{"mainsnak":{"snaktype":"value","property":"P68","hash":"2414322c3bd46b3b2ae0f87c618b0164f5503c44","datavalue":{"value":"https://id.who.int/icd/entity/1363394816","type":"string"},"datatype":"url"},"type":"statement","id":"Q85585$8DD73FEC-5B00-4590-AF87-1A5CA30EF634","rank":"normal"}],"P67":[{"mainsnak":{"snaktype":"value","property":"P67","hash":"eac746ec0900b52311fac5501c9d9518a4c582fc","datavalue":{"value":"CID11:ID_1363394816","type":"string"},"datatype":"string"},"type":"statement","id":"Q85585$2066AA12-51CC-4B55-BF39-632351378892","rank":"normal"}],"P70":[{"mainsnak":{"snaktype":"value","property":"P70","hash":"ea115fe3444d6d42733d60f22b94bc2230307745","datavalue":{"value":"dki-india-ID_1363394816","type":"string"},"datatype":"string"},"type":"statement","id":"Q85585$E31EB197-31DF-4106-9C74-F18242D14AD7","rank":"normal"}],"P86":[{"mainsnak":{"snaktype":"value","property":"P86","hash":"a96031634b9f5dafddaf781bbba3adea6bb64ef4","datavalue":{"value":"Conclu\u00eddo","type":"string"},"datatype":"string"},"type":"statement","id":"Q85585$65B39290-53CB-4331-80C8-F236FAA4CFFC","rank":"normal"}],"P78":[{"mainsnak":{"snaktype":"value","property":"P78","hash":"5f9b5be68b7400da549761cf15abfdbc4d1e075b","datavalue":{"value":"https://pauloleads.com.br/cases-publicos/","type":"string"},"datatype":"url"},"type":"statement","id":"Q85585$680B5F79-EB1D-426C-BC35-2702721B4038","rank":"normal"}],"P80":[{"mainsnak":{"snaktype":"value","property":"P80","hash":"92b8222fcbb75718504f915073a3f43bd4003d18","datavalue":{"value":{"time":"+2026-08-13T00:00:00Z","timezone":0,"before":0,"after":0,"precision":11,"calendarmodel":"http://www.wikidata.org/entity/Q1985727"},"type":"time"},"datatype":"time"},"type":"statement","id":"Q85585$6B7145F5-046D-4F9D-8882-30FFE320EC66","rank":"normal"}]},"sitelinks":{}}}}