{"entities":{"Q84062":{"pageid":74447,"ns":120,"title":"Item:Q84062","lastrevid":454762,"modified":"2026-08-15T09:25:42Z","type":"item","id":"Q84062","labels":{"mul":{"language":"mul","value":"ID_1655474050"},"pt-br":{"language":"pt-br","value":"Miopatia necrosante autoimune"},"en":{"language":"en","value":"Autoimmune necrotising myopathy"}},"descriptions":{"pt-br":{"language":"pt-br","value":"Apresenta fraqueza muscular proximal ocorrendo durante ou ap\u00f3s o tratamento com estatinas; frequentemente associada com eleva\u00e7\u00e3o da creatinoquinase (CK) s\u00e9rica. A fraqueza muscular pode persistir, ap\u00f3s a interrup\u00e7\u00e3o do tratamento com estatinas. Neuropatologicamente d\u00e1 evid\u00eancias de miopatia necrosante com inflama\u00e7\u00e3o escassa. Pode ser necess\u00e1ria terapia imunossupressora._x000D_ _x000D_ Os autoanticorpos neurais associados s\u00e3o anti-SRP (anticorpo de part\u00edcula de reconhecimento de sinal) e anti HMGCR (autoanticorpos que reconhecem 3-hidroxi-3-metilglutaril-coenzima A redutase)"},"en":{"language":"en","value":"Presents with proximal muscle weakness occurring during or after treatment with statins; often associated with elevated serum creatine kinase (CK). The muscle weakness can persist, after discontinuation of statin treatment. Neuropathologically gives evidence of necrotizing myopathy with scarce inflammation. Immune suppressive therapy may be needed. Associated neural autoantibodies are Anti- SRP (signal recognition particle antibody) and anti HMGCR (Autoantibodies recognizing 3-hydroxy-3-methylglutaryl-coenzyme A reductase)"}},"aliases":{},"claims":{"P68":[{"mainsnak":{"snaktype":"value","property":"P68","hash":"b34f7da6d1aa6f1a2d5e11a353e65632b8b87d28","datavalue":{"value":"https://id.who.int/icd/entity/1655474050","type":"string"},"datatype":"url"},"type":"statement","id":"Q84062$5A1937CE-88B2-4CE8-AFD4-C6E0288ED155","rank":"normal"}],"P67":[{"mainsnak":{"snaktype":"value","property":"P67","hash":"57dadf9e471e4dbe094908651747f0e074acd922","datavalue":{"value":"CID11:ID_1655474050","type":"string"},"datatype":"string"},"type":"statement","id":"Q84062$12AEEFBA-0A79-49A8-83E5-062092B68A50","rank":"normal"}],"P70":[{"mainsnak":{"snaktype":"value","property":"P70","hash":"cb6fd0e75f10c138bc8bfc96f40cb2579f86dfdb","datavalue":{"value":"dki-india-ID_1655474050","type":"string"},"datatype":"string"},"type":"statement","id":"Q84062$6B5A8521-62DA-4352-9FCB-4186C7D5E2DC","rank":"normal"}],"P86":[{"mainsnak":{"snaktype":"value","property":"P86","hash":"a96031634b9f5dafddaf781bbba3adea6bb64ef4","datavalue":{"value":"Conclu\u00eddo","type":"string"},"datatype":"string"},"type":"statement","id":"Q84062$E22FC290-7550-4919-97D4-55498A65E8B9","rank":"normal"}],"P78":[{"mainsnak":{"snaktype":"value","property":"P78","hash":"5f9b5be68b7400da549761cf15abfdbc4d1e075b","datavalue":{"value":"https://pauloleads.com.br/cases-publicos/","type":"string"},"datatype":"url"},"type":"statement","id":"Q84062$6A0F0FB1-CA28-4EF0-8A82-B563B1D0E33D","rank":"normal"}],"P80":[{"mainsnak":{"snaktype":"value","property":"P80","hash":"92b8222fcbb75718504f915073a3f43bd4003d18","datavalue":{"value":{"time":"+2026-08-13T00:00:00Z","timezone":0,"before":0,"after":0,"precision":11,"calendarmodel":"http://www.wikidata.org/entity/Q1985727"},"type":"time"},"datatype":"time"},"type":"statement","id":"Q84062$BF4FC3AB-4E07-4FD9-9EDD-1614A1EB5201","rank":"normal"}]},"sitelinks":{}}}}