{"entities":{"Q68028":{"pageid":58406,"ns":120,"title":"Item:Q68028","lastrevid":339070,"modified":"2026-08-14T15:52:26Z","type":"item","id":"Q68028","labels":{"mul":{"language":"mul","value":"ID_1006889224"},"pt-br":{"language":"pt-br","value":"Lissencefalia devida \u00e0 muta\u00e7\u00e3o do gene TUBA1A"},"en":{"language":"en","value":"Lissencephaly due to TUBA1A gene mutation"}},"descriptions":{"pt-br":{"language":"pt-br","value":"Lissencefalia (LIS) devido \u00e0 muta\u00e7\u00e3o TUBA1A \u00e9 uma anomalia cong\u00eanita do desenvolvimento cortical devido \u00e0 migra\u00e7\u00e3o neuronal anormal envolvendo lamina\u00e7\u00e3o neocortical e hipocampal, corpo caloso, cerebelo e tronco cerebral. Um amplo espectro cl\u00ednico pode ser observado, desde crian\u00e7as com epilepsia e d\u00e9ficit intelectual e motor graves at\u00e9 casos com disgenesia cerebral grave no per\u00edodo pr\u00e9-natal levando \u00e0 interrup\u00e7\u00e3o da gravidez devido \u00e0 gravidade do progn\u00f3stico."},"en":{"language":"en","value":"Lissencephaly (LIS) due to TUBA1A mutation is a congenital cortical development anomaly due to abnormal neuronal migration involving neocortical and hippocampal lamination, corpus callosum, cerebellum and brainstem. A large clinical spectrum can be observed, from children with severe epilepsy and intellectual and motor deficit to cases with severe cerebral dysgenesis in the antenatal period leading to pregnancy termination due to the severity of the prognosis."}},"aliases":{},"claims":{"P68":[{"mainsnak":{"snaktype":"value","property":"P68","hash":"ae13f603b8e47bb8e8239b04980b1e456673e38b","datavalue":{"value":"https://id.who.int/icd/entity/1006889224","type":"string"},"datatype":"url"},"type":"statement","id":"Q68028$144D24D0-C947-4A0C-8B20-39D8E84DB901","rank":"normal"}],"P67":[{"mainsnak":{"snaktype":"value","property":"P67","hash":"fd290643bdb6495e5d7aa660cf1a3ff6325d48c8","datavalue":{"value":"CID11:ID_1006889224","type":"string"},"datatype":"string"},"type":"statement","id":"Q68028$D6616E03-8DB4-442B-90DA-15FE6529E316","rank":"normal"}],"P70":[{"mainsnak":{"snaktype":"value","property":"P70","hash":"683344a0cf005454b9913bc1c971e9911e28dc68","datavalue":{"value":"dki-india-ID_1006889224","type":"string"},"datatype":"string"},"type":"statement","id":"Q68028$B20C4651-6396-481C-ABB8-234443A92C21","rank":"normal"}],"P86":[{"mainsnak":{"snaktype":"value","property":"P86","hash":"a96031634b9f5dafddaf781bbba3adea6bb64ef4","datavalue":{"value":"Conclu\u00eddo","type":"string"},"datatype":"string"},"type":"statement","id":"Q68028$842A721F-6792-4CD3-9F6C-778432C906AB","rank":"normal"}],"P78":[{"mainsnak":{"snaktype":"value","property":"P78","hash":"5f9b5be68b7400da549761cf15abfdbc4d1e075b","datavalue":{"value":"https://pauloleads.com.br/cases-publicos/","type":"string"},"datatype":"url"},"type":"statement","id":"Q68028$E9C7DD81-9CD6-4A84-A8AA-6266E1A5E581","rank":"normal"}],"P80":[{"mainsnak":{"snaktype":"value","property":"P80","hash":"92b8222fcbb75718504f915073a3f43bd4003d18","datavalue":{"value":{"time":"+2026-08-13T00:00:00Z","timezone":0,"before":0,"after":0,"precision":11,"calendarmodel":"http://www.wikidata.org/entity/Q1985727"},"type":"time"},"datatype":"time"},"type":"statement","id":"Q68028$EB935B56-CABD-44FB-903E-B5D5137BF791","rank":"normal"}]},"sitelinks":{}}}}