{"entities":{"Q59572":{"pageid":49945,"ns":120,"title":"Item:Q59572","lastrevid":278869,"modified":"2026-08-14T07:05:56Z","type":"item","id":"Q59572","labels":{"mul":{"language":"mul","value":"ID_1184113045"},"pt-br":{"language":"pt-br","value":"Defici\u00eancia m\u00faltipla de carboxilase devida \u00e0 defici\u00eancia da holocarboxilase sintetase"},"en":{"language":"en","value":"Multiple carboxylase deficiency due to holocarboxylase synthetase deficiency"}},"descriptions":{"pt-br":{"language":"pt-br","value":"A defici\u00eancia da holocarboxilase sintetase \u00e9 uma forma precoce de defici\u00eancia de carboxilase m\u00faltipla com risco de morte. \u00c9 um erro inato do metabolismo da biotina, que, se n\u00e3o tratado, \u00e9 caracterizado por v\u00f4mitos, taquipneia, irritabilidade, letargia, dermatite esfoliativa e convuls\u00f5es que pode piorar at\u00e9 chegar ao coma."},"en":{"language":"en","value":"Holocarboxylase synthetase deficiency is a life-threatening early-onset form of multiple carboxylase deficiency (see this term), an inborn error of biotin metabolism, that, if untreated, is characterised by vomiting, tachypnoea, irritability, lethargy, exfoliative dermatitis, and seizures that can worsen to coma."}},"aliases":{},"claims":{"P68":[{"mainsnak":{"snaktype":"value","property":"P68","hash":"cbdf73503c8f80002e79deab1c428889c326ffb3","datavalue":{"value":"https://id.who.int/icd/entity/1184113045","type":"string"},"datatype":"url"},"type":"statement","id":"Q59572$A09E6C9B-21F8-45CC-BECD-BF613158B746","rank":"normal"}],"P67":[{"mainsnak":{"snaktype":"value","property":"P67","hash":"d225811519863437670b4ed1e0e8ce5a94798349","datavalue":{"value":"CID11:ID_1184113045","type":"string"},"datatype":"string"},"type":"statement","id":"Q59572$EF195B7C-D8F0-494E-BC43-12E30BA8CE98","rank":"normal"}],"P70":[{"mainsnak":{"snaktype":"value","property":"P70","hash":"56d5a00742c86aee46b4d489ef65eee67eb4a5ad","datavalue":{"value":"dki-india-ID_1184113045","type":"string"},"datatype":"string"},"type":"statement","id":"Q59572$D4F77D08-1BEE-4487-8637-12D18088920B","rank":"normal"}],"P86":[{"mainsnak":{"snaktype":"value","property":"P86","hash":"a96031634b9f5dafddaf781bbba3adea6bb64ef4","datavalue":{"value":"Conclu\u00eddo","type":"string"},"datatype":"string"},"type":"statement","id":"Q59572$8EE6B948-B85E-4D80-8FFB-8E4D1269C376","rank":"normal"}],"P78":[{"mainsnak":{"snaktype":"value","property":"P78","hash":"5f9b5be68b7400da549761cf15abfdbc4d1e075b","datavalue":{"value":"https://pauloleads.com.br/cases-publicos/","type":"string"},"datatype":"url"},"type":"statement","id":"Q59572$B780DBB4-2F84-44D8-8BA1-085905A24E06","rank":"normal"}],"P80":[{"mainsnak":{"snaktype":"value","property":"P80","hash":"92b8222fcbb75718504f915073a3f43bd4003d18","datavalue":{"value":{"time":"+2026-08-13T00:00:00Z","timezone":0,"before":0,"after":0,"precision":11,"calendarmodel":"http://www.wikidata.org/entity/Q1985727"},"type":"time"},"datatype":"time"},"type":"statement","id":"Q59572$EDBAA4B8-BD31-4838-B805-22A990F60E9B","rank":"normal"}]},"sitelinks":{}}}}