{"entities":{"Q44711":{"pageid":35079,"ns":120,"title":"Item:Q44711","lastrevid":166018,"modified":"2026-08-13T12:18:51Z","type":"item","id":"Q44711","labels":{"mul":{"language":"mul","value":"GB90.41"},"pt-br":{"language":"pt-br","value":"Pseudo-hipoaldosteronismo tipo 1"},"en":{"language":"en","value":"Pseudohypoaldosteronism type 1"}},"descriptions":{"pt-br":{"language":"pt-br","value":"Pseudo-hipoaldosteronismo tipo 1 (PHA1) s\u00e3o formas raras de resist\u00eancia aos mineralocorticoides. PHA1 se apresenta no rec\u00e9m-nascido com perda renal de sal, d\u00e9ficit de crescimento e desidrata\u00e7\u00e3o. Duas formas cl\u00ednicas foram descritas: i) uma forma renal (PHA1 renal) que melhora com a idade e na qual a resist\u00eancia aos mineralocorticoides est\u00e1 restrita ao rim, e ii) uma forma grave generalizada (PHA1 generalizada) que persiste na idade adulta e na qual o mineralocorticoide a resist\u00eancia \u00e9 sist\u00eamica e a perda de sal ocorre em v\u00e1rios \u00f3rg\u00e3os. A heran\u00e7a pode ser autoss\u00f4mica recessiva (arPHA1), que \u00e9 mais grave e persistente do que a forma autoss\u00f4mica dominante (AdPHA1)"},"en":{"language":"en","value":"Pseudohypoaldosteronism type 1 (PHA1) are rare forms of mineralocorticoid resistance. PHA1 presents in the newborn with renal salt wasting, failure to thrive and dehydration. Two clinical forms have been described: i) a renal form (renal PHA1) that improves with age and in which mineralocorticoid resistance is restricted to the kidney, and ii) a generalised severe form (generalised PHA1) that persists into adulthood and in which mineralocorticoid resistance is systemic and salt loss occurs in multiple organs. Inheritance can be autosomal recessive (arPHA1) which is more severe and persistent than the autosomal dominant form (AdPHA1)"}},"aliases":{},"claims":{"P68":[{"mainsnak":{"snaktype":"value","property":"P68","hash":"c24dc0152a2463e7330e7d447b46cf58848fc3f2","datavalue":{"value":"https://id.who.int/icd/entity/1576878036","type":"string"},"datatype":"url"},"type":"statement","id":"Q44711$E97FF12C-D107-490A-9E46-BFD93343C88C","rank":"normal"}],"P67":[{"mainsnak":{"snaktype":"value","property":"P67","hash":"d1472e055d9b426195990fbc53b51651e510f076","datavalue":{"value":"CID11:GB90.41","type":"string"},"datatype":"string"},"type":"statement","id":"Q44711$70B0BA67-48D3-4737-AA0D-A3C4D5E9773E","rank":"normal"}],"P70":[{"mainsnak":{"snaktype":"value","property":"P70","hash":"1384e4b2ac55a80001e233d0a0037adff5abe081","datavalue":{"value":"dki-india-GB90.41","type":"string"},"datatype":"string"},"type":"statement","id":"Q44711$8671C0B8-ACA9-4321-94A1-341BF54550B9","rank":"normal"}],"P86":[{"mainsnak":{"snaktype":"value","property":"P86","hash":"a96031634b9f5dafddaf781bbba3adea6bb64ef4","datavalue":{"value":"Conclu\u00eddo","type":"string"},"datatype":"string"},"type":"statement","id":"Q44711$6B2C9C5B-5615-45D8-8339-80C498A8A893","rank":"normal"}],"P78":[{"mainsnak":{"snaktype":"value","property":"P78","hash":"5f9b5be68b7400da549761cf15abfdbc4d1e075b","datavalue":{"value":"https://pauloleads.com.br/cases-publicos/","type":"string"},"datatype":"url"},"type":"statement","id":"Q44711$91992810-6C1B-4DC6-9ECC-DB911845FCDC","rank":"normal"}],"P80":[{"mainsnak":{"snaktype":"value","property":"P80","hash":"92b8222fcbb75718504f915073a3f43bd4003d18","datavalue":{"value":{"time":"+2026-08-13T00:00:00Z","timezone":0,"before":0,"after":0,"precision":11,"calendarmodel":"http://www.wikidata.org/entity/Q1985727"},"type":"time"},"datatype":"time"},"type":"statement","id":"Q44711$C78FA3C2-1019-4C34-B4B0-2F689F9C4472","rank":"normal"}],"P89":[{"mainsnak":{"snaktype":"value","property":"P89","hash":"acf63eb5c31a2f19cc379f3a6381d3f0e5c7dd1f","datavalue":{"value":{"entity-type":"item","numeric-id":20495,"id":"Q20495"},"type":"wikibase-entityid"},"datatype":"wikibase-item"},"type":"statement","id":"Q44711$66249FBF-B641-4D88-9F5F-4C5A6B8C16B5","rank":"normal"}]},"sitelinks":{}}}}