{"entities":{"Q43976":{"pageid":34344,"ns":120,"title":"Item:Q43976","lastrevid":159579,"modified":"2026-08-13T11:13:42Z","type":"item","id":"Q43976","labels":{"mul":{"language":"mul","value":"EK90.1"},"pt-br":{"language":"pt-br","value":"Displasia difusa de queratin\u00f3citos act\u00ednicos"},"en":{"language":"en","value":"Diffuse actinic keratinocyte dysplasia"}},"descriptions":{"pt-br":{"language":"pt-br","value":"A displasia act\u00ednica difusa se desenvolve ap\u00f3s a exposi\u00e7\u00e3o repetida da pele \u00e0 radia\u00e7\u00e3o ultravioleta, geralmente ao longo de d\u00e9cadas, e resulta de danos cumulativos no DNA dentro dos n\u00facleos dos queratin\u00f3citos epid\u00e9rmicos. Caracteriza-se inicialmente por altera\u00e7\u00f5es cut\u00e2neas difusas sutis, incluindo manchas, eritema, telangiectasia e descama\u00e7\u00e3o fina irregular. \u00c9 visto mais comumente na pele desprotegida do couro cabeludo de homens calvos. Histologicamente h\u00e1 sinais precoces de displasia na epiderme basal. \u00c0 medida que o dano se acumula, as altera\u00e7\u00f5es cl\u00ednicas tornam-se mais pronunciadas com a forma\u00e7\u00e3o de discretas queratoses act\u00ednicas, das quais pode se desenvolver carcinoma de c\u00e9lulas escamosas intraepid\u00e9rmico ou invasivo."},"en":{"language":"en","value":"Diffuse actinic dysplasia develops after repeated exposure of skin to ultraviolet radiation, usually over decades, and results from cumulative DNA damage within the nuclei of epidermal keratinocytes. It is characterised initially by subtle diffuse skin changes including mottling, erythema, telangiectasia and irregular fine scaling. It is seen most commonly on the unprotected scalp skin of bald men. Histologically there are early signs of dysplasia in the basal epidermis. As damage accumulates the clinical changes become more pronounced with the formation of discrete actinic keratoses, from which intraepidermal or invasive squamous cell carcinoma may develop."}},"aliases":{},"claims":{"P68":[{"mainsnak":{"snaktype":"value","property":"P68","hash":"3d5f36eb00953437455f8b5f4b6ff2625e4b410f","datavalue":{"value":"https://id.who.int/icd/entity/1976997748","type":"string"},"datatype":"url"},"type":"statement","id":"Q43976$5A65235E-58DE-4012-A0D1-46B619019D23","rank":"normal"}],"P67":[{"mainsnak":{"snaktype":"value","property":"P67","hash":"6fc9df1b8bb9181cf5749c552d950ebac6812203","datavalue":{"value":"CID11:EK90.1","type":"string"},"datatype":"string"},"type":"statement","id":"Q43976$B9C04BC5-F55F-4A91-8637-193A7EE5B392","rank":"normal"}],"P70":[{"mainsnak":{"snaktype":"value","property":"P70","hash":"21d1525a2268a40a889c903be223d0013c749c45","datavalue":{"value":"dki-india-EK90.1","type":"string"},"datatype":"string"},"type":"statement","id":"Q43976$4EE66B16-B324-4B5B-B551-F713CE3ADA2E","rank":"normal"}],"P86":[{"mainsnak":{"snaktype":"value","property":"P86","hash":"a96031634b9f5dafddaf781bbba3adea6bb64ef4","datavalue":{"value":"Conclu\u00eddo","type":"string"},"datatype":"string"},"type":"statement","id":"Q43976$1690B28F-9B9F-4B9D-987A-44F20C444E15","rank":"normal"}],"P78":[{"mainsnak":{"snaktype":"value","property":"P78","hash":"5f9b5be68b7400da549761cf15abfdbc4d1e075b","datavalue":{"value":"https://pauloleads.com.br/cases-publicos/","type":"string"},"datatype":"url"},"type":"statement","id":"Q43976$BB11262E-48E7-445E-ACD6-05F47F988405","rank":"normal"}],"P80":[{"mainsnak":{"snaktype":"value","property":"P80","hash":"92b8222fcbb75718504f915073a3f43bd4003d18","datavalue":{"value":{"time":"+2026-08-13T00:00:00Z","timezone":0,"before":0,"after":0,"precision":11,"calendarmodel":"http://www.wikidata.org/entity/Q1985727"},"type":"time"},"datatype":"time"},"type":"statement","id":"Q43976$FB500D81-F61F-401D-AD4B-6E574918B951","rank":"normal"}],"P89":[{"mainsnak":{"snaktype":"value","property":"P89","hash":"60fa8da3c9c09378f6d0b24f460c93e54b647623","datavalue":{"value":{"entity-type":"item","numeric-id":19521,"id":"Q19521"},"type":"wikibase-entityid"},"datatype":"wikibase-item"},"type":"statement","id":"Q43976$E052FE12-9D4E-48BB-A84D-F2E5EC7061FF","rank":"normal"}]},"sitelinks":{}}}}