{"entities":{"Q41487":{"pageid":31855,"ns":120,"title":"Item:Q41487","lastrevid":138546,"modified":"2026-08-13T07:40:07Z","type":"item","id":"Q41487","labels":{"mul":{"language":"mul","value":"8E4A"},"pt-br":{"language":"pt-br","value":"Transtornos paraneopl\u00e1sicos ou autoimunes do sistema nervoso"},"en":{"language":"en","value":"Paraneoplastic or autoimmune disorders of the nervous system"}},"descriptions":{"pt-br":{"language":"pt-br","value":"Transtornos paraneopl\u00e1sicos e autoimunes do sistema nervoso resultam de um ataque imunol\u00f3gico direcionado a neur\u00f4nios ou c\u00e9lulas gliais no sistema nervoso central (p.ex., encefalopatia, ataxia, mielite) ou perif\u00e9rico (neuropatias perif\u00e9ricas ou auton\u00f4micas, transtornos da jun\u00e7\u00e3o neuromuscular ou miopatia). No contexto paraneopl\u00e1sico, esse ataque \u00e9 uma consequ\u00eancia de uma resposta imune potencialmente eficaz ao tumor iniciada por ant\u00edgenos onconeurais derivados de um c\u00e2ncer sist\u00eamico. No contexto n\u00e3o paraneopl\u00e1sico denominado autoimune, a etiologia permanece indefinida, embora evid\u00eancias crescentes indiquem um gatilho infeccioso anterior em pelo menos alguns casos. Esses transtornos s\u00e3o comumente multifocais causando les\u00f5es e sintomas decorrentes do envolvimento em v\u00e1rios n\u00edveis do sistema nervoso. Uma hist\u00f3ria pessoal ou familiar de autoimunidade \u00e9 frequentemente encontrada. Concomitantemente podem ser encontrados autoanticorpos neurais e anticorpos n\u00e3o \u00f3rg\u00e3o-espec\u00edficos (anticorpos peroxidase da tireoide [TPO]). O perfil de autoanticorpos neurais pode ser preditivo de um tipo espec\u00edfico de c\u00e2ncer e pode estar associado a um fen\u00f3tipo neurol\u00f3gico particular. A exclus\u00e3o de etiologias alternativas (p.ex., infec\u00e7\u00f5es) \u00e9 importante. A resposta a imunoterapia pode apoiar o diagn\u00f3stico."},"en":{"language":"en","value":"Paraneoplastic and autoimmune disorders of the nervous system result from a targeted immune attack on neurons or glial cells in the central (e.g. encephalopathy, ataxia, myelitis) or peripheral nervous systems (peripheral or autonomic neuropathies, neuromuscular junction disorders or myopathy). In the paraneoplastic context, this attack is a consequence of a potentially effective tumour immune response initiated by onco-neural antigens derived from a systemic cancer. In the non-paraneoplastic context termed autoimmune the etiology remains elusive though increasing evidence indicates a preceding infectious trigger in at least some cases. These disorders are commonly multifocal causing injury and symptoms arising from involvement at many levels of the nervous system. A personal or family history of autoimmunity is often found. Accompanying neural and non-organ specific (thyroid peroxidase [TPO] antibodies) autoantibodies may be found. The neural autoantibody profile may be predictive of a specific cancer type and may be associated with a particular neurological phenotype. Exclusion of alternative etiologies (e.g. infections) is important. Response to immunotherapy may support the diagnosis."}},"aliases":{},"claims":{"P68":[{"mainsnak":{"snaktype":"value","property":"P68","hash":"03b3f46d54d0c7fe4a7bae3e9c294259251bc1eb","datavalue":{"value":"https://id.who.int/icd/entity/1058231555","type":"string"},"datatype":"url"},"type":"statement","id":"Q41487$FAB76A3D-8E5E-4511-857F-E62C9713AA30","rank":"normal"}],"P67":[{"mainsnak":{"snaktype":"value","property":"P67","hash":"fdeba273b5fe5a59709d58e80eca01049442e69a","datavalue":{"value":"CID11:8E4A","type":"string"},"datatype":"string"},"type":"statement","id":"Q41487$3AB78B68-30AC-47B1-AB5A-4E80F70DD57A","rank":"normal"}],"P70":[{"mainsnak":{"snaktype":"value","property":"P70","hash":"2957f1c0663602e413383eb78e8bb26dc0de2374","datavalue":{"value":"dki-india-8E4A","type":"string"},"datatype":"string"},"type":"statement","id":"Q41487$F5318BB8-6499-49FE-A2F6-3BB864C241B6","rank":"normal"}],"P86":[{"mainsnak":{"snaktype":"value","property":"P86","hash":"a96031634b9f5dafddaf781bbba3adea6bb64ef4","datavalue":{"value":"Conclu\u00eddo","type":"string"},"datatype":"string"},"type":"statement","id":"Q41487$AFD16DC4-5972-4C51-B049-AEB96967A745","rank":"normal"}],"P78":[{"mainsnak":{"snaktype":"value","property":"P78","hash":"5f9b5be68b7400da549761cf15abfdbc4d1e075b","datavalue":{"value":"https://pauloleads.com.br/cases-publicos/","type":"string"},"datatype":"url"},"type":"statement","id":"Q41487$03F8E44F-794E-4D58-94A0-DFDD036ED3AF","rank":"normal"}],"P80":[{"mainsnak":{"snaktype":"value","property":"P80","hash":"92b8222fcbb75718504f915073a3f43bd4003d18","datavalue":{"value":{"time":"+2026-08-13T00:00:00Z","timezone":0,"before":0,"after":0,"precision":11,"calendarmodel":"http://www.wikidata.org/entity/Q1985727"},"type":"time"},"datatype":"time"},"type":"statement","id":"Q41487$D6B6675D-D8C4-4CE6-A20D-FBA2F2446415","rank":"normal"}],"P89":[{"mainsnak":{"snaktype":"value","property":"P89","hash":"92f1d7572d413768dbf946a76a14960f01ddc44c","datavalue":{"value":{"entity-type":"item","numeric-id":41486,"id":"Q41486"},"type":"wikibase-entityid"},"datatype":"wikibase-item"},"type":"statement","id":"Q41487$139E90F3-4703-4B84-BA57-843EF1CDECB6","rank":"normal"}]},"sitelinks":{}}}}