{"entities":{"Q41479":{"pageid":31847,"ns":120,"title":"Item:Q41479","lastrevid":138506,"modified":"2026-08-13T07:39:44Z","type":"item","id":"Q41479","labels":{"mul":{"language":"mul","value":"8E4A.1"},"pt-br":{"language":"pt-br","value":"Transtornos paraneopl\u00e1sicos ou autoimunes do sistema nervoso perif\u00e9rico ou aut\u00f4nomo"},"en":{"language":"en","value":"Paraneoplastic or autoimmune disorders of the peripheral or autonomic nervous system"}},"descriptions":{"pt-br":{"language":"pt-br","value":"Transtornos paraneopl\u00e1sicos e autoimunes do sistema nervoso perif\u00e9rico e aut\u00f4nomo resultam de um ataque imune direcionado a neur\u00f4nios ou c\u00e9lulas gliais do sistema nervoso perif\u00e9rico (neuropatias perif\u00e9ricas ou auton\u00f4micas). No contexto paraneopl\u00e1sico, esse ataque \u00e9 uma consequ\u00eancia de uma resposta imune potencialmente eficaz ao tumor iniciada por ant\u00edgenos onconeurais derivados de um c\u00e2ncer sist\u00eamico. No contexto n\u00e3o paraneopl\u00e1sico denominado autoimune, a etiologia permanece indefinida, embora evid\u00eancias crescentes indiquem um gatilho infeccioso anterior em pelo menos alguns casos. O in\u00edcio pode ser subagudo ou insidioso e esses transtornos podem ser limitados, multifocais ou generalizados. Os transtornos nervosos perif\u00e9ricos som\u00e1ticos autoimunes podem afetar o nervo em v\u00e1rios n\u00edveis, incluindo raiz, nervo e plexo e podem ser axonais, desmielinizantes ou ambos. Os transtornos auton\u00f4micos autoimunes resultam em insufici\u00eancia auton\u00f4mica que pode ser parcial ou generalizada. A neuropatia auton\u00f4mica protot\u00edpica \u00e9 a ganglionopatia autoimune associada a anticorpos direcionados ao receptor nicot\u00ednico ganglionar de acetilcolina (\u03b13 gAChR). Rastreamento de c\u00e2ncer \u00e9 apropriado para aqueles com perfis espec\u00edficos de anticorpos neurais e outros fatores de risco._x000D_ _x000D_ Anticorpos neurais associados em neuropatias perif\u00e9ricas incluem anticorpos anti-n\u00facleo nervoso tipo 1 ou anti-Hu, CASPR2, gAChR, ganglios\u00eddeo (GM1 IgG e IGM)."},"en":{"language":"en","value":"Paraneoplastic and autoimmune disorders of the peripheral and autonomic nervous system result from a targeted immune attack on neurons or glial cells in the peripheral nervous systems (peripheral or autonomic neuropathies). In the paraneoplastic context, this attack is a consequence of a potentially effective tumour immune response initiated by onco-neural antigens derived from a systemic cancer. In the non-paraneoplastic context termed autoimmune the etiology remains elusive though increasing evidence indicates a preceding infectious trigger in at least some cases. Onset may be subacute or insidious and these disorders may be limited, multifocal or generalised. Autoimmune somatic peripheral nerve disorders may affect the nerve at multiple levels including root, nerve and plexus and may be axonal, demyelinating or both. Autoimmune autonomic disorders result in autonomic failure that can be partial or generalised. The prototypic autonomic neuropathy is the autoimmune ganglionopathy associated with antibodies targeting the ganglionic nicotinic acetylcholine receptor (\u03b13 gAChR). Screening for cancer is appropriate for those with specific neural antibody profiles and other risk factors. Associated neural antibodies in peripheral neuropathies include anti neuronal nuclear antibody type 1 or anti-Hu, CASPR2, gAChR, ganglioside (GM1 IgG and IGM) antibodies."}},"aliases":{},"claims":{"P68":[{"mainsnak":{"snaktype":"value","property":"P68","hash":"8a32ec8e94b1019576113e2862345f1abad680e7","datavalue":{"value":"https://id.who.int/icd/entity/1029892421","type":"string"},"datatype":"url"},"type":"statement","id":"Q41479$DBE1FD39-18B7-47EC-BA50-6336D3CFE8E9","rank":"normal"}],"P67":[{"mainsnak":{"snaktype":"value","property":"P67","hash":"17db197c3696c7bd8982ec8b23c9ef7561d32823","datavalue":{"value":"CID11:8E4A.1","type":"string"},"datatype":"string"},"type":"statement","id":"Q41479$24635882-7D06-4637-B612-54C3DE17E32E","rank":"normal"}],"P70":[{"mainsnak":{"snaktype":"value","property":"P70","hash":"c3d30d70c7f7d4845f55ec28ec874e2abe64f8ba","datavalue":{"value":"dki-india-8E4A.1","type":"string"},"datatype":"string"},"type":"statement","id":"Q41479$FC4E22B3-653D-4B6B-966D-26609FCD5868","rank":"normal"}],"P86":[{"mainsnak":{"snaktype":"value","property":"P86","hash":"a96031634b9f5dafddaf781bbba3adea6bb64ef4","datavalue":{"value":"Conclu\u00eddo","type":"string"},"datatype":"string"},"type":"statement","id":"Q41479$514503A0-DBA5-478E-A68F-98AB5BCFCCE7","rank":"normal"}],"P78":[{"mainsnak":{"snaktype":"value","property":"P78","hash":"5f9b5be68b7400da549761cf15abfdbc4d1e075b","datavalue":{"value":"https://pauloleads.com.br/cases-publicos/","type":"string"},"datatype":"url"},"type":"statement","id":"Q41479$5119CAE3-790A-4980-9E46-8B32973E13CF","rank":"normal"}],"P80":[{"mainsnak":{"snaktype":"value","property":"P80","hash":"92b8222fcbb75718504f915073a3f43bd4003d18","datavalue":{"value":{"time":"+2026-08-13T00:00:00Z","timezone":0,"before":0,"after":0,"precision":11,"calendarmodel":"http://www.wikidata.org/entity/Q1985727"},"type":"time"},"datatype":"time"},"type":"statement","id":"Q41479$8AB28451-669F-4F9D-9E0B-48A82F700370","rank":"normal"}],"P89":[{"mainsnak":{"snaktype":"value","property":"P89","hash":"a617677c050864ca38b92ab8f7c5100ed47c5564","datavalue":{"value":{"entity-type":"item","numeric-id":41478,"id":"Q41478"},"type":"wikibase-entityid"},"datatype":"wikibase-item"},"type":"statement","id":"Q41479$486ACD9A-D188-4A5E-ACF1-403F768DA95B","rank":"normal"}]},"sitelinks":{}}}}