{"entities":{"Q41046":{"pageid":31414,"ns":120,"title":"Item:Q41046","lastrevid":134886,"modified":"2026-08-13T07:05:58Z","type":"item","id":"Q41046","labels":{"mul":{"language":"mul","value":"8B61"},"pt-br":{"language":"pt-br","value":"Atrofia muscular espinal"},"en":{"language":"en","value":"Spinal muscular atrophy"}},"descriptions":{"pt-br":{"language":"pt-br","value":"A atrofia muscular espinhal (AMS) \u00e9 uma doen\u00e7a progressiva com perda de c\u00e9lulas do corno anterior, levando \u00e0 fraqueza e a perda muscular. A fraqueza \u00e9 tipicamente sim\u00e9trica. Normalmente, os sinais do neur\u00f4nio motor superior est\u00e3o ausentes e n\u00e3o h\u00e1 d\u00e9ficit sensitivo. A alimenta\u00e7\u00e3o e a degluti\u00e7\u00e3o podem ser afetadas e pode ocorrer envolvimento dos m\u00fasculos respirat\u00f3rios. AMS \u00e9 um transtorno autoss\u00f4mico recessivo ligado ao cromossomo 5q13 e \u00e9 causado pela dele\u00e7\u00e3o ou muta\u00e7\u00e3o do gene SMN 1 (neur\u00f4nio motor espinal 1). Os quatro tipos de AMS I, II, III e IV s\u00e3o categorizados com base na idade de in\u00edcio da doen\u00e7a e na capacidade de atingir marcos motores."},"en":{"language":"en","value":"Spinal muscular atrophy (SMA) is a progressive disorder with loss of anterior horn cells leading to muscle weakness and wasting. The weakness is typically symmetrical. Typically, upper motor neuron signs are absent and there is no sensory deficit. Feeding and swallowing can be affected, and involvement of respiratory muscles may occur. SMA is an autosomal recessive disorder linked to chromosome 5q13 and the disorder is caused by deletion or mutation of SMN 1 (spinal motor neuron 1) gene. The four types of SMA I, II, III and IV are categorised based on the age of onset of the disease and the ability to achieve motor milestones."}},"aliases":{},"claims":{"P68":[{"mainsnak":{"snaktype":"value","property":"P68","hash":"9ca7adc7537b319e72c2796208556c8c67f9960e","datavalue":{"value":"https://id.who.int/icd/entity/71074342","type":"string"},"datatype":"url"},"type":"statement","id":"Q41046$EB39CC2B-F650-4B68-BE27-3E34CCEBAD8E","rank":"normal"}],"P67":[{"mainsnak":{"snaktype":"value","property":"P67","hash":"dbd91a37ac8d88f230bebc2ed10d33536b5152c7","datavalue":{"value":"CID11:8B61","type":"string"},"datatype":"string"},"type":"statement","id":"Q41046$2CFE344A-4AB5-42EF-89DD-297791AB1805","rank":"normal"}],"P70":[{"mainsnak":{"snaktype":"value","property":"P70","hash":"d54701280f8b78e214017d391ca2ee073b47b0d6","datavalue":{"value":"dki-india-8B61","type":"string"},"datatype":"string"},"type":"statement","id":"Q41046$A7269819-4D3B-4DB0-8350-FEDAD9F9A437","rank":"normal"}],"P86":[{"mainsnak":{"snaktype":"value","property":"P86","hash":"a96031634b9f5dafddaf781bbba3adea6bb64ef4","datavalue":{"value":"Conclu\u00eddo","type":"string"},"datatype":"string"},"type":"statement","id":"Q41046$350B62AA-E6FC-4838-902C-237512F2B618","rank":"normal"}],"P78":[{"mainsnak":{"snaktype":"value","property":"P78","hash":"5f9b5be68b7400da549761cf15abfdbc4d1e075b","datavalue":{"value":"https://pauloleads.com.br/cases-publicos/","type":"string"},"datatype":"url"},"type":"statement","id":"Q41046$A9B4FBBF-4C01-4F2F-A5F4-5906EB40FBBC","rank":"normal"}],"P80":[{"mainsnak":{"snaktype":"value","property":"P80","hash":"92b8222fcbb75718504f915073a3f43bd4003d18","datavalue":{"value":{"time":"+2026-08-13T00:00:00Z","timezone":0,"before":0,"after":0,"precision":11,"calendarmodel":"http://www.wikidata.org/entity/Q1985727"},"type":"time"},"datatype":"time"},"type":"statement","id":"Q41046$7B93248D-98E0-4B45-BE88-F4CAEE272331","rank":"normal"}],"P89":[{"mainsnak":{"snaktype":"value","property":"P89","hash":"daa6746ced56658902542ddc1a87f5dcc6588e17","datavalue":{"value":{"entity-type":"item","numeric-id":16826,"id":"Q16826"},"type":"wikibase-entityid"},"datatype":"wikibase-item"},"type":"statement","id":"Q41046$851BFF63-6934-46A7-A254-04E90F1DCDF8","rank":"normal"}]},"sitelinks":{}}}}