{"entities":{"Q39991":{"pageid":30359,"ns":120,"title":"Item:Q39991","lastrevid":125622,"modified":"2026-08-13T05:37:36Z","type":"item","id":"Q39991","labels":{"mul":{"language":"mul","value":"5C50.11"},"pt-br":{"language":"pt-br","value":"Tirosinemia tipo 1"},"en":{"language":"en","value":"Tyrosinaemia type 1"}},"descriptions":{"pt-br":{"language":"pt-br","value":"A tirosinemia tipo 1 \u00e9 um erro inato do metabolismo dos amino\u00e1cidos, caracterizada por manifesta\u00e7\u00f5es hepatorrenais. A forma aguda de in\u00edcio precoce da doen\u00e7a se manifesta entre 15 dias a 3 meses ap\u00f3s o nascimento com necrose hepatocelular. A septicemia \u00e9 uma complica\u00e7\u00e3o frequente. A disfun\u00e7\u00e3o tubular renal ocorre e est\u00e1 associada \u00e0 perda de fosfato e raquitismo hipofosfat\u00eamico. Uma forma de in\u00edcio tardio tamb\u00e9m foi descrita e se manifesta com raquitismo resistente a vitaminas, causado por disfun\u00e7\u00e3o tubular renal."},"en":{"language":"en","value":"Tyrosinemia type 1 is an inborn error of amino acid metabolism characterised by hepatorenal manifestations. The early-onset acute form of the disorder manifests between 15 days and 3 months after birth with hepatocellular necrosis. Septicaemia is a frequent complication. Renal tubular dysfunction occurs and is associated with phosphate loss and hypophosphatemic rickets. A later onset form has also been described and manifests with vitamin-resistant rickets caused by renal tubular dysfunction."}},"aliases":{},"claims":{"P68":[{"mainsnak":{"snaktype":"value","property":"P68","hash":"17a3f77eb71ad1589b4e2118b89fdbbfc063afaf","datavalue":{"value":"https://id.who.int/icd/entity/2029519782","type":"string"},"datatype":"url"},"type":"statement","id":"Q39991$895E3B4A-D526-4F84-8F35-B1630FC1375A","rank":"normal"}],"P67":[{"mainsnak":{"snaktype":"value","property":"P67","hash":"e7c2541f61414ea69d5705815170950d3c09a97c","datavalue":{"value":"CID11:5C50.11","type":"string"},"datatype":"string"},"type":"statement","id":"Q39991$B573DBD4-C86D-4011-8B41-A7697A471027","rank":"normal"}],"P70":[{"mainsnak":{"snaktype":"value","property":"P70","hash":"02c97a0f3cdad400e254de1a40f237a462899d52","datavalue":{"value":"dki-india-5C50.11","type":"string"},"datatype":"string"},"type":"statement","id":"Q39991$79A1281A-FE94-4657-A506-543C7DA49F9D","rank":"normal"}],"P86":[{"mainsnak":{"snaktype":"value","property":"P86","hash":"a96031634b9f5dafddaf781bbba3adea6bb64ef4","datavalue":{"value":"Conclu\u00eddo","type":"string"},"datatype":"string"},"type":"statement","id":"Q39991$7EB2223C-AD11-4225-B0A9-5206D0139B49","rank":"normal"}],"P78":[{"mainsnak":{"snaktype":"value","property":"P78","hash":"5f9b5be68b7400da549761cf15abfdbc4d1e075b","datavalue":{"value":"https://pauloleads.com.br/cases-publicos/","type":"string"},"datatype":"url"},"type":"statement","id":"Q39991$E273C430-A1C3-4325-99A6-06BD02513CE8","rank":"normal"}],"P80":[{"mainsnak":{"snaktype":"value","property":"P80","hash":"92b8222fcbb75718504f915073a3f43bd4003d18","datavalue":{"value":{"time":"+2026-08-13T00:00:00Z","timezone":0,"before":0,"after":0,"precision":11,"calendarmodel":"http://www.wikidata.org/entity/Q1985727"},"type":"time"},"datatype":"time"},"type":"statement","id":"Q39991$F399FCAA-A79B-40F1-9711-262E3DDB73E2","rank":"normal"}],"P89":[{"mainsnak":{"snaktype":"value","property":"P89","hash":"7dc35e62e5c86f588951340ab3d695170436a232","datavalue":{"value":{"entity-type":"item","numeric-id":15552,"id":"Q15552"},"type":"wikibase-entityid"},"datatype":"wikibase-item"},"type":"statement","id":"Q39991$5BEC75D8-44CE-4714-B6B8-9A3E51325279","rank":"normal"}]},"sitelinks":{}}}}