{"entities":{"Q39745":{"pageid":30113,"ns":120,"title":"Item:Q39745","lastrevid":123413,"modified":"2026-08-13T05:16:36Z","type":"item","id":"Q39745","labels":{"mul":{"language":"mul","value":"4B24"},"pt-br":{"language":"pt-br","value":"Doen\u00e7a do enxerto versus hospedeiro"},"en":{"language":"en","value":"Graft-versus-host disease"}},"descriptions":{"pt-br":{"language":"pt-br","value":"Doen\u00e7a do enxerto-versus-hospedeiro (GVHD) ocorre quando c\u00e9lulas linfoides de um doador imunocompetente s\u00e3o introduzidas num receptor histo-incompat\u00edvel incapaz de rejeit\u00e1-las. Isso usualmente ocorre como resultado de transplante de c\u00e9lulas tronco hematopoi\u00e9ticas. Os principais alvos dos linf\u00f3citos do doador s\u00e3o a pele, o trato gastrointestinal e o f\u00edgado do receptor. A GVHD aguda, que ocorre normalmente nos primeiros 100 dias, tem alta mortalidade. A fase aguda pode ser seguida por GVHD cr\u00f4nica, que tamb\u00e9m pode sofrer nova agudiza\u00e7\u00e3o. Isso, geralmente, se apresenta como uma erup\u00e7\u00e3o liquenoide, mas pode evoluir para grave doen\u00e7a fibrosante afetando pele, pulm\u00f5es e f\u00edgado."},"en":{"language":"en","value":"Graft-versus-host disease (GVHD) occurs when lymphoid cells from an immunocompetent donor are introduced into a histo-incompatible recipient incapable of rejecting them. This usually occurs as a result of haematopoietic stem cell transplantation. The main targets attacked by the donor lymphocytes are the recipient\u2019s skin, gastrointestinal tract and liver. Acute GVHD, normally occurring within the first 100 days following transplantation, has a high mortality. The acute phase may be followed by chronic GVHD, which can also arise de novo. This usually presents as a lichenoid rash but can develop into a severe fibrosing disease affecting skin, lungs and liver."}},"aliases":{},"claims":{"P68":[{"mainsnak":{"snaktype":"value","property":"P68","hash":"2cca372052ddaafbae3934ef441f9c900f650043","datavalue":{"value":"https://id.who.int/icd/entity/437372167","type":"string"},"datatype":"url"},"type":"statement","id":"Q39745$B1EA00EA-EB9C-473B-B233-7889A98B1FA7","rank":"normal"}],"P67":[{"mainsnak":{"snaktype":"value","property":"P67","hash":"bb18f966237bd3db8fb75bc75e081957e440295f","datavalue":{"value":"CID11:4B24","type":"string"},"datatype":"string"},"type":"statement","id":"Q39745$CE443070-4AEA-40F1-8B96-4BFC8D1FFC44","rank":"normal"}],"P70":[{"mainsnak":{"snaktype":"value","property":"P70","hash":"3f84ae453b93e24fd5a12da5312d8a87b1e08ebb","datavalue":{"value":"dki-india-4B24","type":"string"},"datatype":"string"},"type":"statement","id":"Q39745$8B8E18AE-78A0-45A5-9FBF-0F8DA362620E","rank":"normal"}],"P86":[{"mainsnak":{"snaktype":"value","property":"P86","hash":"a96031634b9f5dafddaf781bbba3adea6bb64ef4","datavalue":{"value":"Conclu\u00eddo","type":"string"},"datatype":"string"},"type":"statement","id":"Q39745$AB52A508-EF81-49BA-BAE7-CBC5339164BF","rank":"normal"}],"P78":[{"mainsnak":{"snaktype":"value","property":"P78","hash":"5f9b5be68b7400da549761cf15abfdbc4d1e075b","datavalue":{"value":"https://pauloleads.com.br/cases-publicos/","type":"string"},"datatype":"url"},"type":"statement","id":"Q39745$71C62D52-EDDD-46A0-B80A-74AEA19E3D41","rank":"normal"}],"P80":[{"mainsnak":{"snaktype":"value","property":"P80","hash":"92b8222fcbb75718504f915073a3f43bd4003d18","datavalue":{"value":{"time":"+2026-08-13T00:00:00Z","timezone":0,"before":0,"after":0,"precision":11,"calendarmodel":"http://www.wikidata.org/entity/Q1985727"},"type":"time"},"datatype":"time"},"type":"statement","id":"Q39745$6EE14F70-C1AB-4750-AF4D-F8680C947399","rank":"normal"}],"P89":[{"mainsnak":{"snaktype":"value","property":"P89","hash":"5e35ffb0a49805b5692735b053adc06752a4ff58","datavalue":{"value":{"entity-type":"item","numeric-id":14976,"id":"Q14976"},"type":"wikibase-entityid"},"datatype":"wikibase-item"},"type":"statement","id":"Q39745$037D81CA-326C-4C69-ABAF-58025D08D798","rank":"normal"}]},"sitelinks":{}}}}