{"entities":{"Q102707":{"pageid":93100,"ns":120,"title":"Item:Q102707","lastrevid":589465,"modified":"2026-08-16T19:54:45Z","type":"item","id":"Q102707","labels":{"mul":{"language":"mul","value":"ID_1594688835"},"pt-br":{"language":"pt-br","value":"Agamaglobulinemia ligada ao X"},"en":{"language":"en","value":"X-linked agammaglobulinaemia"}},"descriptions":{"pt-br":{"language":"pt-br","value":"Agamaglobulinemia ligada ao X \u00e9 uma doen\u00e7a heredit\u00e1ria recessiva ligada ao X marcada por infec\u00e7\u00f5es bacterianas recorrentes nas vias a\u00e9reas e no trato GI. Tamb\u00e9m predisp\u00f5e os indiv\u00edduos afetados a infec\u00e7\u00f5es cr\u00f4nicas por enterov\u00edrus. Ocorre com uma preval\u00eancia de aproximadamente 1:200.000. A doen\u00e7a \u00e9 causada pela produ\u00e7\u00e3o deficiente de imunoglobulina como resultado de muta\u00e7\u00f5es no gene que codifica a tirosina quinase de Bruton (Btk) e \u00e9 caracterizada por comprometimento da matura\u00e7\u00e3o dos linf\u00f3citos B. Os pacientes s\u00e3o tratados com inje\u00e7\u00f5es endovenosas ou subcut\u00e2neas regulares de imunoglobulina."},"en":{"language":"en","value":"X-linked agammaglobulinemia is an X-linked recessive inherited disease marked by recurrent bacterial infections in the airways and GI tract. It also predisposes affected individuals to chronic enterovirus infections. It occurs with a prevalence of approximately 1:200,000. The disease is caused by the deficient production of immunoglobulin as a result of mutations in the gene coding for Bruton's tyrosine kinase (Btk) and is characterised by impaired maturation of B lymphocytes. Patients are treated with regular venous or subcutaneous injections of immunoglobulin."}},"aliases":{},"claims":{"P68":[{"mainsnak":{"snaktype":"value","property":"P68","hash":"f5e0230ca8d56978b90ee66d6c68ece683bf6bec","datavalue":{"value":"https://id.who.int/icd/entity/1594688835","type":"string"},"datatype":"url"},"type":"statement","id":"Q102707$B8007871-90CE-439E-AD67-F92A5165B49E","rank":"normal"}],"P67":[{"mainsnak":{"snaktype":"value","property":"P67","hash":"27168b704da5277c02e5919d4a820c087e0bd2ee","datavalue":{"value":"CID11:ID_1594688835","type":"string"},"datatype":"string"},"type":"statement","id":"Q102707$2CC75F63-4343-4E73-80C0-B6F4ABD57069","rank":"normal"}],"P70":[{"mainsnak":{"snaktype":"value","property":"P70","hash":"d5000df6aebb81c9896b832d0021da6332262847","datavalue":{"value":"dki-india-ID_1594688835","type":"string"},"datatype":"string"},"type":"statement","id":"Q102707$8AA5400B-FAD7-4C56-A786-4C37440BFEC0","rank":"normal"}],"P86":[{"mainsnak":{"snaktype":"value","property":"P86","hash":"a96031634b9f5dafddaf781bbba3adea6bb64ef4","datavalue":{"value":"Conclu\u00eddo","type":"string"},"datatype":"string"},"type":"statement","id":"Q102707$D58F4CBE-D416-4AA3-AF58-41FF36045EFC","rank":"normal"}],"P78":[{"mainsnak":{"snaktype":"value","property":"P78","hash":"5f9b5be68b7400da549761cf15abfdbc4d1e075b","datavalue":{"value":"https://pauloleads.com.br/cases-publicos/","type":"string"},"datatype":"url"},"type":"statement","id":"Q102707$12588504-AA21-4D62-8968-0AD0033E687A","rank":"normal"}],"P80":[{"mainsnak":{"snaktype":"value","property":"P80","hash":"378ac503ed43f21e1f461d2823a6ad59da580514","datavalue":{"value":{"time":"+2026-08-15T00:00:00Z","timezone":0,"before":0,"after":0,"precision":11,"calendarmodel":"http://www.wikidata.org/entity/Q1985727"},"type":"time"},"datatype":"time"},"type":"statement","id":"Q102707$6FD31110-BB1B-4385-992C-501F5B9A2DFB","rank":"normal"}]},"sitelinks":{}}}}